ID   STE4_SCHPO              Reviewed;         264 AA.
AC   P36622;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 145.
DE   RecName: Full=Sexual differentiation protein ste4;
GN   Name=ste4; ORFNames=SPAC1565.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=1766866; DOI=10.1093/nar/19.25.7043;
RA   Okazaki N., Okazaki K., Tanaka K., Okayama H.;
RT   "The ste4+ gene, essential for sexual differentiation of
RT   Schizosaccharomyces pombe, encodes a protein with a leucine zipper motif.";
RL   Nucleic Acids Res. 19:7043-7047(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Essential for mating and meiosis.
CC   -!- SUBUNIT: Homodimer or heterodimer with another leucine-zipper protein.
CC       {ECO:0000305}.
CC   -!- INDUCTION: By nitrogen starvation.
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DR   EMBL; X61924; CAA43926.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAB99271.1; -; Genomic_DNA.
DR   PIR; S22600; S22600.
DR   RefSeq; NP_593283.1; NM_001018713.2.
DR   AlphaFoldDB; P36622; -.
DR   SMR; P36622; -.
DR   BioGRID; 278173; 7.
DR   DIP; DIP-683N; -.
DR   IntAct; P36622; 1.
DR   STRING; 4896.SPAC1565.04c.1; -.
DR   iPTMnet; P36622; -.
DR   MaxQB; P36622; -.
DR   PaxDb; P36622; -.
DR   EnsemblFungi; SPAC1565.04c.1; SPAC1565.04c.1:pep; SPAC1565.04c.
DR   GeneID; 2541677; -.
DR   KEGG; spo:SPAC1565.04c; -.
DR   PomBase; SPAC1565.04c; ste4.
DR   VEuPathDB; FungiDB:SPAC1565.04c; -.
DR   eggNOG; KOG4375; Eukaryota.
DR   HOGENOM; CLU_1054333_0_0_1; -.
DR   InParanoid; P36622; -.
DR   OMA; NYALVIC; -.
DR   PhylomeDB; P36622; -.
DR   PRO; PR:P36622; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; EXP:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0071507; P:pheromone response MAPK cascade; IMP:PomBase.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Meiosis; Reference proteome; Stress response.
FT   CHAIN           1..264
FT                   /note="Sexual differentiation protein ste4"
FT                   /id="PRO_0000072264"
FT   DOMAIN          11..73
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   DOMAIN          176..264
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   REGION          111..139
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   264 AA;  30736 MW;  A41EC113BB221905 CRC64;
     MGDSDDFYWN WNNEAVCNWI EQLGFPHKEA FEDYHILGKD IDLLSSNDLR DMGIESVGHR
     IDILSAIQSM KKQQKDKLQQ ENKDQELKNI EESYKKLEEK TEHLSDDNVS LEKRVEYLET
     ENTKLVKTLN SLNSEFLQLL RKIAINVKEG RQLTTENSSD TSSMTHPVQP SPSVLGSFDL
     EVNDSLTNAE KNRKLNVNLT YNEVLCSMLQ RYRIDPNTWM SYDLLINYDD KEHAIPMDVK
     PLQLFRNLQK RGKSPSFVLS RRSC