ID   STC_ANGAU               Reviewed;         250 AA.
AC   P18301;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Stanniocalcin;
DE            Short=STC;
DE   AltName: Full=Corpuscles of Stannius protein;
DE            Short=CS;
DE   AltName: Full=Hypocalcin;
DE   AltName: Full=Teleocalcin;
DE   Flags: Precursor;
GN   Name=stc;
OS   Anguilla australis (Australian eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 33-57.
RX   PubMed=3319739; DOI=10.1016/0303-7207(87)90149-3;
RA   Butkus A., Roche P.J., Fernley R.T., Haralambidis J., Penschow J.D.,
RA   Ryan G.B., Trahair J.F., Tregear G.W., Coghlan J.P.;
RT   "Purification and cloning of a corpuscles of Stannius protein from Anguilla
RT   australis.";
RL   Mol. Cell. Endocrinol. 54:123-133(1987).
RN   [2]
RP   SEQUENCE REVISION.
RA   Roche P.J.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC       release into the circulation, it lowers calcium transport by the gills,
CC       thereby reducing its rate of influx from the environment into the
CC       extracellular compartment. STC also stimulates phosphate reabsorption
CC       by renal proximal tubules. The consequence of this action is increased
CC       levels of plasma phosphate, which combines with excess calcium and
CC       promotes its disposal into bone and scales.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- TISSUE SPECIFICITY: Corpuscles of Stannius.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; M36967; AAB91483.1; -; mRNA.
DR   PIR; A54648; A54648.
DR   AlphaFoldDB; P18301; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..32
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033308"
FT   CHAIN           33..250
FT                   /note="Stanniocalcin"
FT                   /id="PRO_0000033309"
FT   REGION          228..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..113
FT                   /evidence="ECO:0000250"
FT   DISULFID        97..127
FT                   /evidence="ECO:0000250"
FT   DISULFID        134..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        201
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   250 AA;  27174 MW;  BB972BD951F75B3E CRC64;
     MLRMSGLILT LVLVTAAYEQ DESEPLSPRT ARFSASSPSD VARCLNGALQ VGCSAFACLD
     NSTCNTDGMH EICRSFLHGA AKFDTQGKTF VKESLKCIAN GITSKVFLTI RRCSSFQKMI
     SEVQEECYSK LDLCSVAQSN PEAMGEVAQV PSQFPNRYYS TLLQSLLTCD EDTVEQVRAG
     LVSRLEPEMG VLFQLLQTKA CPPSAAGGTG PVGAGGSWRW PMGPPMFKIQ PNLRSRDPTH
     LFAKKRSTSS