SSN8_NEUCR
ID SSN8_NEUCR Reviewed; 345 AA.
AC Q9HE63; Q1K4X6; V5INM8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN Name=ssn8; Synonyms=srb11; ORFNames=B21O8.140, NCU01563;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Component of the srb8-11 complex. The srb8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The srb8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The srb8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the srb8-11 complex, a regulatory module of the
CC Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC18151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL451012; CAC18151.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM002237; ESA43662.1; -; Genomic_DNA.
DR EMBL; CM002237; ESA43663.1; -; Genomic_DNA.
DR RefSeq; XP_011393463.1; XM_011395161.1.
DR RefSeq; XP_011393464.1; XM_011395162.1.
DR AlphaFoldDB; Q9HE63; -.
DR SMR; Q9HE63; -.
DR STRING; 5141.EFNCRP00000001871; -.
DR EnsemblFungi; ESA43662; ESA43662; NCU01563.
DR EnsemblFungi; ESA43663; ESA43663; NCU01563.
DR GeneID; 3872362; -.
DR KEGG; ncr:NCU01563; -.
DR VEuPathDB; FungiDB:NCU01563; -.
DR HOGENOM; CLU_034754_2_0_1; -.
DR InParanoid; Q9HE63; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR028367; CyclinC/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 3: Inferred from homology;
KW Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..345
FT /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT /id="PRO_0000314279"
FT DOMAIN 53..144
FT /note="Cyclin N-terminal"
FT REGION 256..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 38472 MW; CEC9D08665126B8C CRC64;
MAANYWESTQ RKHWLFTKDE LAAMRAKLEA EEPNLVASFP LPQLRHLNIY FNQQINRLGK
RMGLRQQALA TAQVYIKRFY TKVEIRRTNP HHVLVTALYL ACKMEECPQH IRLMANEARG
FWPTDFQSQT EVARIGECEF YLISEMSSHL IVHSPYRTLT SLQGELGLAQ EDVNLAWSVI
NDHYMTDLPL LHPPHVIALT AILLALVLRQ DPSGRLPGTA ASASGLVAAS AALAQAQAQA
QARAAMMAGG GQTVPGLTPQ SSSGLQAMLP PQSPAGEGPA EGNKNPRMAK VHRFAAWLSD
SNIDIEAMVD CTQELISFYE CHEQYNDKNT REQINRFVKA RGLDK
