ID   SSL1_STAAE              Reviewed;         226 AA.
AC   A0A0H3KAV3;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Staphylococcal superantigen-like 1 {ECO:0000303|PubMed:30609641};
DE            EC=3.4.21.- {ECO:0000269|PubMed:30609641};
DE   Flags: Precursor;
GN   Name=ssl1 {ECO:0000303|PubMed:30609641}; OrderedLocusNames=NWMN_0388;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=30609641; DOI=10.3390/pathogens8010002;
RA   Tang A., Caballero A.R., Bierdeman M.A., Marquart M.E., Foster T.J.,
RA   Monk I.R., O'Callaghan R.J.;
RT   "Staphylococcus aureus Superantigen-Like Protein SSL1: A Toxic Protease.";
RL   Pathogens 8:0-0(2019).
CC   -!- FUNCTION: Mediates virulence by proteolytically cleaving host proteins,
CC       including collagens types I and IV as well as human cytokines IL8,
CC       IL17A, and IFN-gamma. {ECO:0000269|PubMed:30609641}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:30609641}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2G1S8}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP009351; BAF66660.1; -; Genomic_DNA.
DR   RefSeq; WP_000669005.1; NZ_CP023390.1.
DR   AlphaFoldDB; A0A0H3KAV3; -.
DR   SMR; A0A0H3KAV3; -.
DR   EnsemblBacteria; BAF66660; BAF66660; NWMN_0388.
DR   KEGG; sae:NWMN_0388; -.
DR   HOGENOM; CLU_054950_1_0_9; -.
DR   OMA; HIGANIM; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR015282; SSL_OB.
DR   InterPro; IPR008375; Staph_exotoxin.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   Pfam; PF09199; SSL_OB; 1.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   PRINTS; PR01800; STAPHEXOTOXN.
DR   PRINTS; PR01501; TOXICSSTOXIN.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Protease; Secreted; Signal; Virulence.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..226
FT                   /note="Staphylococcal superantigen-like 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5002613332"
SQ   SEQUENCE   226 AA;  25647 MW;  729D9B2D02571A27 CRC64;
     MKFKAIAKAS LALGMLATGV ITSNVQSVQA KAEVKQQSES ELKHYYNKPI LERKNVTGFK
     YTDEGKHYLE VTVGQQHSRI TLLGSDKDKF KDGENSNIDV FILREGDSRQ ATNYSIGGVT
     KSNSVQYIDY INTPILEIKK DNEDVLKDFY YISKEDISLK ELDYRLRERA IKQHGLYSNG
     LKQGQITITM NDGTTHTIDL SQKLEKERMG ESIDGTKINK ILVEMK