ID   SRX22_SARPE             Reviewed;         294 AA.
AC   P24489;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Sarcotoxin II-2;
DE   Flags: Precursor;
OS   Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Boettcherisca.
OX   NCBI_TaxID=7386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2247051; DOI=10.1128/mcb.10.12.6114-6122.1990;
RA   Kanai A., Natori S.;
RT   "Analysis of a gene cluster for sarcotoxin II, a group of antibacterial
RT   proteins of Sarcophaga peregrina.";
RL   Mol. Cell. Biol. 10:6114-6122(1990).
CC   -!- FUNCTION: Sarcotoxin II is an antibacterial protein which plays a role
CC       in the inflammatory response of this insect. The main effect of
CC       sarcotoxin II on E.coli may be the inhibition of cell wall synthesis,
CC       including septum formation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized by the fat body and is eventually
CC       secreted into the hemolymph.
CC   -!- INDUCTION: In response to injury of the body wall of the larvae.
CC   -!- MISCELLANEOUS: Sarcotoxin II consists of at least four structurally
CC       related proteins named sarcotoxin IIa, II-1, II-2, and II-3.
CC   -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR   EMBL; D90154; BAA14183.1; -; Genomic_DNA.
DR   PIR; B36351; B36351.
DR   AlphaFoldDB; P24489; -.
DR   SMR; P24489; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR005521; Attacin_C.
DR   InterPro; IPR005520; Attacin_N.
DR   Pfam; PF03769; Attacin_C; 1.
DR   Pfam; PF03768; Attacin_N; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Pyrrolidone carboxylic acid; Repeat; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PROPEP          23..24
FT                   /note="Removed by a dipeptidylpeptidase"
FT                   /id="PRO_0000004887"
FT   CHAIN           25..293
FT                   /note="Sarcotoxin II-2"
FT                   /id="PRO_0000004888"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         293
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   294 AA;  30856 MW;  3F8B69674DF67180 CRC64;
     MKSFVFFAAC FAIVALNSLA HAYPQKLPVP IPPPTNPPVA AFHNSVATNS KGGQDVSVKL
     AATNLGNKHV QPIAEVFAKG NTQGGNVLRG ATVGVQGHGL GASVTKTQDG IAESFRKQAE
     ANLRLGDSAS LIGKVSQTDT KIKGIDFKPQ LSSSSLALQG DRLGASISRD VNRGVSDTLT
     KSISANVFRN DNHNLDASVF RSDVRQNNGF NFQKTGGMLD YSHANGHGLN AGLTRFSGIG
     NQANVGGYST LFRSNDGLTS LKANAGGSQW LSGPFANQRD YSFGLGLSHN AWRG