SPA9_HUMAN
ID SPA9_HUMAN Reviewed; 417 AA.
AC Q86WD7; B4DVH4; B9ZVX3; Q2T9J2; Q6UWP9; Q86WD4; Q86WD5; Q86WD6; Q86YP6;
AC Q86YP7;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Serpin A9;
DE AltName: Full=Centerin;
DE AltName: Full=Germinal center B-cell-expressed transcript 1 protein;
DE Flags: Precursor;
GN Name=SERPINA9; Synonyms=GCET1, SERPINA11; ORFNames=UNQ692/PRO1337;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6 AND 7), VARIANT ALA-330, AND
RP TISSUE SPECIFICITY.
RX PubMed=12819018; DOI=10.1016/s0002-9440(10)63637-1;
RA Pan Z., Shen Y., Du C., Zhou G., Rosenwald A., Staudt L.M., Greiner T.C.,
RA McKeithan T.W., Chan W.C.;
RT "Two newly characterized germinal center B-cell-associated genes, GCET1 and
RT GCET2, have differential expression in normal and neoplastic B cells.";
RL Am. J. Pathol. 163:135-144(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Blood;
RA Ju S.G., Zhang X.G.;
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LEU-218;
RP GLN-236; ILE-292 AND ALA-330.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, AND TISSUE SPECIFICITY.
RX PubMed=17447896; DOI=10.1042/bj20070174;
RA Paterson M.A., Horvath A.J., Pike R.N., Coughlin P.B.;
RT "Molecular characterization of centerin, a germinal centre cell serpin.";
RL Biochem. J. 405:489-494(2007).
RN [8]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=18550480; DOI=10.1309/9qke68qu7b825a3u;
RA Paterson M.A., Hosking P.S., Coughlin P.B.;
RT "Expression of the serpin centerin defines a germinal center phenotype in
RT B-cell lymphomas.";
RL Am. J. Clin. Pathol. 130:117-126(2008).
RN [9]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=17898315; DOI=10.1182/blood-2007-06-094151;
RA Montes-Moreno S., Roncador G., Maestre L., Martinez N., Sanchez-Verde L.,
RA Camacho F.I., Cannata J., Martinez-Torrecuadrada J.L., Shen Y., Chan W.C.,
RA Piris M.A.;
RT "Gcet1 (centerin), a highly restricted marker for a subset of germinal
RT center-derived lymphomas.";
RL Blood 111:351-358(2008).
CC -!- FUNCTION: Protease inhibitor that inhibits trypsin and trypsin-like
CC serine proteases (in vitro). Inhibits plasmin and thrombin with lower
CC efficiency (in vitro). {ECO:0000269|PubMed:17447896}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Secreted.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 7]: Membrane {ECO:0000305}; Single-pass
CC type II membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1; Synonyms=A;
CC IsoId=Q86WD7-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q86WD7-2; Sequence=VSP_041491, VSP_041493;
CC Name=3; Synonyms=SERPINA11a;
CC IsoId=Q86WD7-3; Sequence=VSP_041492;
CC Name=4; Synonyms=SERPINA11b;
CC IsoId=Q86WD7-4; Sequence=VSP_041490, VSP_041494, VSP_041495;
CC Name=5;
CC IsoId=Q86WD7-5; Sequence=VSP_041488;
CC Name=6;
CC IsoId=Q86WD7-6; Sequence=VSP_041489;
CC Name=7;
CC IsoId=Q86WD7-7; Sequence=VSP_041491;
CC -!- TISSUE SPECIFICITY: Highly expressed in normal germinal center (GC) B-
CC cells and GC B-cell-derived malignancies. {ECO:0000269|PubMed:12819018,
CC ECO:0000269|PubMed:17447896, ECO:0000269|PubMed:17898315,
CC ECO:0000269|PubMed:18550480}.
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO32345.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AY220118; AAO65242.1; -; mRNA.
DR EMBL; AY220119; AAO65243.1; -; mRNA.
DR EMBL; AY220120; AAO65244.1; -; mRNA.
DR EMBL; AY220121; AAO65245.1; -; mRNA.
DR EMBL; AY185496; AAO32345.1; ALT_SEQ; mRNA.
DR EMBL; AY185497; AAO32346.1; -; mRNA.
DR EMBL; AY358700; AAQ89063.1; -; mRNA.
DR EMBL; AK301082; BAG62686.1; -; mRNA.
DR EMBL; AL132708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111498; AAI11499.1; -; mRNA.
DR CCDS; CCDS41982.1; -. [Q86WD7-1]
DR CCDS; CCDS61542.1; -. [Q86WD7-5]
DR RefSeq; NP_001035983.1; NM_001042518.1.
DR RefSeq; NP_001271204.1; NM_001284275.1. [Q86WD7-6]
DR RefSeq; NP_001271205.1; NM_001284276.1. [Q86WD7-5]
DR RefSeq; NP_783866.2; NM_175739.3. [Q86WD7-1]
DR RefSeq; XP_011535016.1; XM_011536714.2. [Q86WD7-1]
DR RefSeq; XP_011535017.1; XM_011536715.2. [Q86WD7-1]
DR RefSeq; XP_011535018.1; XM_011536716.2. [Q86WD7-6]
DR RefSeq; XP_011535019.1; XM_011536717.1. [Q86WD7-6]
DR AlphaFoldDB; Q86WD7; -.
DR SMR; Q86WD7; -.
DR BioGRID; 130609; 16.
DR STRING; 9606.ENSP00000337133; -.
DR MEROPS; I04.082; -.
DR GlyGen; Q86WD7; 2 sites.
DR iPTMnet; Q86WD7; -.
DR PhosphoSitePlus; Q86WD7; -.
DR BioMuta; SERPINA9; -.
DR DMDM; 215274213; -.
DR MassIVE; Q86WD7; -.
DR PaxDb; Q86WD7; -.
DR PeptideAtlas; Q86WD7; -.
DR PRIDE; Q86WD7; -.
DR ProteomicsDB; 70149; -. [Q86WD7-3]
DR ProteomicsDB; 70150; -. [Q86WD7-4]
DR Antibodypedia; 56037; 168 antibodies from 25 providers.
DR DNASU; 327657; -.
DR Ensembl; ENST00000337425.10; ENSP00000337133.5; ENSG00000170054.16. [Q86WD7-7]
DR Ensembl; ENST00000380365.7; ENSP00000369723.3; ENSG00000170054.16. [Q86WD7-1]
DR Ensembl; ENST00000424550.6; ENSP00000409012.2; ENSG00000170054.16. [Q86WD7-5]
DR Ensembl; ENST00000448305.6; ENSP00000414092.2; ENSG00000170054.16. [Q86WD7-6]
DR Ensembl; ENST00000538527.5; ENSP00000441511.1; ENSG00000170054.16. [Q86WD7-3]
DR Ensembl; ENST00000674164.1; ENSP00000501328.1; ENSG00000170054.16. [Q86WD7-2]
DR Ensembl; ENST00000674397.2; ENSP00000501517.1; ENSG00000170054.16. [Q86WD7-1]
DR GeneID; 327657; -.
DR KEGG; hsa:327657; -.
DR MANE-Select; ENST00000674397.2; ENSP00000501517.1; NM_175739.4; NP_783866.3.
DR UCSC; uc001yde.4; human. [Q86WD7-1]
DR CTD; 327657; -.
DR DisGeNET; 327657; -.
DR GeneCards; SERPINA9; -.
DR HGNC; HGNC:15995; SERPINA9.
DR HPA; ENSG00000170054; Tissue enriched (lymphoid).
DR MIM; 615677; gene.
DR neXtProt; NX_Q86WD7; -.
DR OpenTargets; ENSG00000170054; -.
DR PharmGKB; PA38077; -.
DR VEuPathDB; HostDB:ENSG00000170054; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000162880; -.
DR HOGENOM; CLU_023330_2_1_1; -.
DR InParanoid; Q86WD7; -.
DR OMA; NCSVLQM; -.
DR OrthoDB; 1124079at2759; -.
DR PhylomeDB; Q86WD7; -.
DR TreeFam; TF343201; -.
DR PathwayCommons; Q86WD7; -.
DR BioGRID-ORCS; 327657; 8 hits in 1060 CRISPR screens.
DR ChiTaRS; SERPINA9; human.
DR GeneWiki; SERPINA9; -.
DR GenomeRNAi; 327657; -.
DR Pharos; Q86WD7; Tbio.
DR PRO; PR:Q86WD7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q86WD7; protein.
DR Bgee; ENSG00000170054; Expressed in epithelium of nasopharynx and 40 other tissues.
DR ExpressionAtlas; Q86WD7; baseline and differential.
DR Genevisible; Q86WD7; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:UniProtKB.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Glycoprotein; Membrane;
KW Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..417
FT /note="Serpin A9"
FT /id="PRO_0000041971"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 390
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..417
FT /note="MASYLYGVLFAVGLCAPIYCVSPANAPSAYPRPSSTKSTPASQVYSLNTDFA
FT FRLYRRLVLETPSQNIFFSPVSVSTSLAMLSLGAHSVTKTQILQGLGFNLTHTPESAIH
FT QGFQHLVHSLTVPSKDLTLKMGSALFVKKELQLQANFLGNVKRLYEAEVFSTDFSNPSI
FT AQARINSHVKKKTQGKVVDIIQGLDLLTAMVLVNHIFFKAKWEKPFHPEYTRKNFPFLV
FT GEQVTVHVPMMHQKEQFAFGVDTELNCFVLQMDYKGDAVAFFVLPSKGKMRQLEQALSA
FT RTLRKWSHSLQKRWIEVFIPRFSISASYNLETILPKMGIQNVFDKNADFSGIAKRDSLQ
FT VSKATHKAVLDVSEEGTEATAATTTKFIVRSKDGPSYFTVSFNRTFLMMITNKATDGIL
FT FLGKVENPTKS -> MRSAGGRGEIKVRRELQPSKQVSGLTNHARTGQEKRNLQRHILF
FT QNGILPLWSTLCCWPLCSNLLCVPGQCPQCIPPPFLHKEHPCLTGVFPQHRLCLPPIPQ
FT AGFGDPESEHLLLPCECLHFPGHALPWGPLSHQDPDSPGPGLQPHTHTRVCHPPGLPAP
FT GSLTDCSQQRPDLEDGKCPLRQEGAAAAGKFLGQCQEAV (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_041492"
FT VAR_SEQ 1..131
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:12819018"
FT /id="VSP_041488"
FT VAR_SEQ 1..80
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:12819018"
FT /id="VSP_041489"
FT VAR_SEQ 1..57
FT /note="MASYLYGVLFAVGLCAPIYCVSPANAPSAYPRPSSTKSTPASQVYSLNTDFA
FT FRLYR -> MRSAGGRGEIKVRRELQPSKQVSGLTNHARTGQEKRNLQ (in
FT isoform 4)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_041490"
FT VAR_SEQ 1
FT /note="M -> MQGQGRRRGTCKDIFCSKM (in isoform 2 and isoform
FT 7)"
FT /evidence="ECO:0000303|PubMed:12819018,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_041491"
FT VAR_SEQ 73..172
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12819018"
FT /id="VSP_041493"
FT VAR_SEQ 351..352
FT /note="AT -> VS (in isoform 4)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_041494"
FT VAR_SEQ 353..417
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_041495"
FT VARIANT 24
FT /note="A -> V (in dbSNP:rs4905204)"
FT /id="VAR_047344"
FT VARIANT 218
FT /note="P -> L (in dbSNP:rs17090921)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_047345"
FT VARIANT 236
FT /note="H -> Q (in dbSNP:rs28583900)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_047346"
FT VARIANT 292
FT /note="R -> I (in dbSNP:rs28618118)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_047347"
FT VARIANT 330
FT /note="V -> A (in dbSNP:rs11628722)"
FT /evidence="ECO:0000269|PubMed:12819018,
FT ECO:0000269|PubMed:12975309"
FT /id="VAR_047348"
FT CONFLICT 23
FT /note="P -> L (in Ref. 1; AAO65242/AAO65243 and 3;
FT AAQ89063)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="Q -> E (in Ref. 4; BAG62686)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="R -> G (in Ref. 1; AAO65245)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="F -> S (in Ref. 4; BAG62686)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="N -> D (in Ref. 1; AAO65242)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="L -> P (in Ref. 1; AAO65244)"
FT /evidence="ECO:0000305"
FT CONFLICT 371
FT /note="T -> A (in Ref. 1; AAO65242)"
FT /evidence="ECO:0000305"
FT CONFLICT 411
FT /note="V -> A (in Ref. 1; AAO65243 and 4; BAG62686)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 46557 MW; C7693D34FD2E12AB CRC64;
MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD FAFRLYRRLV
LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF NLTHTPESAI HQGFQHLVHS
LTVPSKDLTL KMGSALFVKK ELQLQANFLG NVKRLYEAEV FSTDFSNPSI AQARINSHVK
KKTQGKVVDI IQGLDLLTAM VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM
HQKEQFAFGV DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK
RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK ATHKAVLDVS
EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK ATDGILFLGK VENPTKS
