ID   SP110_LACTC             Reviewed;         838 AA.
AC   C5DJH6;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Spindle pole body component 110;
DE   AltName: Full=Spindle pole body spacer protein SPC110;
GN   Name=SPC110; OrderedLocusNames=KLTH0F16500g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) required for the
CC       proper execution of spindle pole body (SPB) duplication. Potential role
CC       in cross-linking filaments or anchoring other molecules. It is
CC       essential for growth (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, spindle pole body {ECO:0000250}.
CC       Note=Tightly associated with the nucleus. It is present in a granular
CC       pattern that excludes the nucleolus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC110 family. {ECO:0000305}.
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DR   EMBL; CU928170; CAR24465.1; -; Genomic_DNA.
DR   RefSeq; XP_002554902.1; XM_002554856.1.
DR   AlphaFoldDB; C5DJH6; -.
DR   SMR; C5DJH6; -.
DR   STRING; 559295.C5DJH6; -.
DR   EnsemblFungi; CAR24465; CAR24465; KLTH0F16500g.
DR   GeneID; 8293135; -.
DR   KEGG; lth:KLTH0F16500g; -.
DR   eggNOG; ENOG502QUTQ; Eukaryota.
DR   HOGENOM; CLU_329279_0_0_1; -.
DR   InParanoid; C5DJH6; -.
DR   OMA; EISMYQE; -.
DR   OrthoDB; 1115170at2759; -.
DR   Proteomes; UP000002036; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040593; Spc110_C.
DR   Pfam; PF18520; Spc110_C; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..838
FT                   /note="Spindle pole body component 110"
FT                   /id="PRO_0000409201"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          163..644
FT                   /evidence="ECO:0000255"
FT   COILED          682..709
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        287..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   838 AA;  97072 MW;  B027BCE9347B929B CRC64;
     MSDSPGTPNG KDTIRNYEFT PIGYVKERET SVPAVANSDS RKRSSPYRSP AADDDGPPQK
     AFRADDTLNS TRIFNDSSFD DTLPSQSVMN SVRINGVSDL HDNGIEEENG GASNPLKEQQ
     ETLYKLNVEN YNLRVKCNSL LKFLNNVTDE GELRKNLAVI DELQEWKGKY QELKKAYRSL
     QLKFDQSEHK DQADLEQDAR SNEKEMRSLQ KKLQEYQEQV TQSKKLVESL ENKLGNSASG
     SKEIKEQFEH KSSLLQERID KLESELAAKD KELEINRNEI KNLQNDLQKA NHDSSSLADQ
     KLQTRSKEIE NLNNRLKSAV REREAAEHLL KESQNALRSL RAELSTLRQE SDRKLDDLSV
     AKEKSERVLK ERLEERTSQS ERLQQRANSL EQNAAELSSR LQLRDQRIKA LEDEARELQK
     MNQRIQDLND GKDSEKLQAQ NQKLDGLRSE IERIKNEKEE LERDNDKLKK RIVAQATKSP
     ALKANSRKSL EKDAEAEKLR SRVRELEQEL RVSKDALNKL RHNYRRDTDE LKLQLEGAET
     DQVSAKRSLE KEIDRLKFEI DSLRESRKDE IAIMENRFNL LRRENEQLSG QGGSQLASLQ
     KSLTEKQKEI NELVQRCSDN TMDRLKLNRE LAKAQEAESE GKREASKLSA RLEFITKEFV
     KYKEAKTQGG EAGADRLNEK WSEKYQHMKQ RLLNELKVLQ EENLELERAT LERKGSAGSG
     TYNVGMSSLQ DQLDYYRLKY HREVAHTNDL NVMNDYLNRV LRASAQHVRL DILKLENEAP
     PDAFPEFTYR GRLRFKTVAL FVLAAVRVQR VSLKLRWDSQ RLNYLQKKIA LEQDKITW