ID   SP110_KLULA             Reviewed;         858 AA.
AC   Q6CMB5;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Spindle pole body component 110;
DE   AltName: Full=Spindle pole body spacer protein SPC110;
GN   Name=SPC110; OrderedLocusNames=KLLA0E21517g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) required for the
CC       proper execution of spindle pole body (SPB) duplication. Potential role
CC       in cross-linking filaments or anchoring other molecules. It is
CC       essential for growth (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, spindle pole body {ECO:0000250}.
CC       Note=Tightly associated with the nucleus. It is present in a granular
CC       pattern that excludes the nucleolus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC110 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAH00011.1; -; Genomic_DNA.
DR   RefSeq; XP_454924.1; XM_454924.1.
DR   AlphaFoldDB; Q6CMB5; -.
DR   SMR; Q6CMB5; -.
DR   STRING; 28985.XP_454924.1; -.
DR   EnsemblFungi; CAH00011; CAH00011; KLLA0_E21517g.
DR   GeneID; 2894617; -.
DR   KEGG; kla:KLLA0_E21517g; -.
DR   eggNOG; ENOG502QUTQ; Eukaryota.
DR   HOGENOM; CLU_329279_0_0_1; -.
DR   InParanoid; Q6CMB5; -.
DR   OMA; EISMYQE; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040593; Spc110_C.
DR   Pfam; PF18520; Spc110_C; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..858
FT                   /note="Spindle pole body component 110"
FT                   /id="PRO_0000409200"
FT   COILED          118..725
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   858 AA;  100674 MW;  2F9DA1CFEBE67C7A CRC64;
     MSSVMETPHA GKLKKYEFTP IGYAEEKRKE GIDLLKENGL KRSLESGSDL PAERKRVRNP
     SVVDETFSST RLFNDTSFDE TVPEGIIQER RPNSRKNLVD DLLIKDQETT ENLTSNPLKE
     TESSLKKLQM ENYNLRIKCT SLLKFLNNIS DDGEIVKNLE ILDELDDLKV RYRQLNLDYT
     ALQKQCDRIE DQNDEHEDIA KLKESNDKLK EELRSTKENL IDTDAQLQQL KDTIKSLENK
     IFNMRTEQTE KECQHGMQVD LLQSKINETS TSLTSKEREC SDLKEKIKWL TSQLQEFDHQ
     SGSLLDLQST LDSKNEAIRN LEAQLQRNEH QRQSLEREVS LLQEELSSIR ETHQKIITHK
     DQQIKQLTEN LSSSDSEAVK RLNELSSERL RLLETNKSLK FSEKDLKQTV KSLEDQLNSC
     QEELHASQDK HKEKVSELLR KQLPYTSSEV EAMRQELLEM RKSNDILKTE NNSLSRRLDN
     LIRQSPSKKS VEVDIQRKNN EIRALRSTVK DLEHELQDVT SNVSKLKENH KEEIQKLRKQ
     VNPDLPTDVL EEKSKLQNRI SLLQMELNSI KDTKEKELAM WRRKYETIRR SNEELLQEGK
     DQSGQLSNIL NEKDKEILQL QSRFNSLLTE KNSLLNELSK VRSHKDDYKE ELKKNQSRLE
     FITKEFVKLK DASKQAENSE DAKDILNNKW YSKYQSMKDK FLGELKSLQD ENLELQKSLL
     KQKANPNSTA EVFSKTTEKG TLKDEIDYYR LKYANEVKQN NDLKTMNQYL NRVLRASSQH
     VKLDILKLQN EVPVYNPYAD IPFHNMRFSH QKIKFKTVAL LVLSCIRMKT TIEARRWDRQ
     RLDYLKRKIV LNQDNISW