SOXR_SALTY
ID SOXR_SALTY Reviewed; 152 AA.
AC P0A2R0; Q56144;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Redox-sensitive transcriptional activator SoxR;
GN Name=soxR; OrderedLocusNames=STM4266;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RA Martins E.A.L., Demple B.;
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Activates the transcription of the soxS gene which itself
CC controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-
CC sulfur cluster that may act as a redox sensor system that recognizes
CC superoxide. The variable redox state of the Fe-S cluster is employed in
CC vivo to modulate the transcriptional activity of SoxR in response to
CC specific types of oxidative stress (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR EMBL; U61147; AAB03869.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL23090.1; -; Genomic_DNA.
DR RefSeq; NP_463131.1; NC_003197.2.
DR RefSeq; WP_000412686.1; NC_003197.2.
DR AlphaFoldDB; P0A2R0; -.
DR SMR; P0A2R0; -.
DR STRING; 99287.STM4266; -.
DR PaxDb; P0A2R0; -.
DR EnsemblBacteria; AAL23090; AAL23090; STM4266.
DR GeneID; 1255792; -.
DR KEGG; stm:STM4266; -.
DR PATRIC; fig|99287.12.peg.4487; -.
DR HOGENOM; CLU_060077_5_1_6; -.
DR OMA; IHFYEAK; -.
DR PhylomeDB; P0A2R0; -.
DR BioCyc; SENT99287:STM4266-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd01110; HTH_SoxR; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR010211; Redox-sen_tscrpt-act_SoxR.
DR InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR PANTHER; PTHR30204:SF0; PTHR30204:SF0; 1.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF09278; MerR-DNA-bind; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR TIGRFAMs; TIGR01950; SoxR; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Activator; DNA-binding; Iron; Iron-sulfur; Metal-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..152
FT /note="Redox-sensitive transcriptional activator SoxR"
FT /id="PRO_0000098153"
FT DOMAIN 11..79
FT /note="HTH merR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT DNA_BIND 14..33
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT REGION 119..130
FT /note="Might be part of a sensor region"
FT BINDING 119
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 122
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 124
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 130
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT CONFLICT 27
FT /note="A -> P (in Ref. 1; AAB03869)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 152 AA; 16875 MW; 57AA8AF5D908316F CRC64;
MEKKSPRLKA LLTPGEVAKR SGVAVSALHF YESKGLITSI RNSGNQRRYK RDVLRYVAII
KIAQRIGIPL ATIGDAFGIL PEGHTLSAKE WKQLSSQWRE ELDRRIHTLV ALRDELDGCI
GCGCLSRSDC PLRNPGDRLG EHGTGARLLE DD
