SNPC3_MOUSE
ID SNPC3_MOUSE Reviewed; 407 AA.
AC Q9D2C9; Q8C0A5;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=snRNA-activating protein complex subunit 3;
DE Short=SNAPc subunit 3;
DE AltName: Full=Small nuclear RNA-activating complex polypeptide 3;
GN Name=Snapc3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, Medulla oblongata, Ovary, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC proximal sequence element (PSE), a non-TATA-box basal promoter element
CC common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC TATA box (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNAPC3/SRD2 family. {ECO:0000305}.
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DR EMBL; AK019863; BAB31890.2; -; mRNA.
DR EMBL; AK031870; BAC27585.1; -; mRNA.
DR EMBL; AK049933; BAC33990.1; -; mRNA.
DR EMBL; BC048713; AAH48713.1; -; mRNA.
DR CCDS; CCDS38792.1; -.
DR RefSeq; NP_084225.1; NM_029949.3.
DR RefSeq; XP_006538432.1; XM_006538369.3.
DR RefSeq; XP_006538433.1; XM_006538370.3.
DR RefSeq; XP_006538435.1; XM_006538372.3.
DR RefSeq; XP_011248436.1; XM_011250134.2.
DR RefSeq; XP_017175944.1; XM_017320455.1.
DR RefSeq; XP_017175945.1; XM_017320456.1.
DR AlphaFoldDB; Q9D2C9; -.
DR STRING; 10090.ENSMUSP00000030206; -.
DR iPTMnet; Q9D2C9; -.
DR PhosphoSitePlus; Q9D2C9; -.
DR EPD; Q9D2C9; -.
DR jPOST; Q9D2C9; -.
DR PaxDb; Q9D2C9; -.
DR PRIDE; Q9D2C9; -.
DR ProteomicsDB; 261533; -.
DR Antibodypedia; 10045; 141 antibodies from 23 providers.
DR DNASU; 77634; -.
DR Ensembl; ENSMUST00000030206; ENSMUSP00000030206; ENSMUSG00000028483.
DR Ensembl; ENSMUST00000123262; ENSMUSP00000124038; ENSMUSG00000028483.
DR Ensembl; ENSMUST00000124856; ENSMUSP00000124181; ENSMUSG00000028483.
DR Ensembl; ENSMUST00000143533; ENSMUSP00000123793; ENSMUSG00000028483.
DR GeneID; 77634; -.
DR KEGG; mmu:77634; -.
DR UCSC; uc008tku.1; mouse.
DR CTD; 6619; -.
DR MGI; MGI:1916338; Snapc3.
DR VEuPathDB; HostDB:ENSMUSG00000028483; -.
DR eggNOG; KOG2664; Eukaryota.
DR GeneTree; ENSGT00390000005708; -.
DR HOGENOM; CLU_041861_0_1_1; -.
DR InParanoid; Q9D2C9; -.
DR OMA; WSEAHDR; -.
DR OrthoDB; 1595999at2759; -.
DR PhylomeDB; Q9D2C9; -.
DR TreeFam; TF317705; -.
DR Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR BioGRID-ORCS; 77634; 24 hits in 75 CRISPR screens.
DR ChiTaRS; Snapc3; mouse.
DR PRO; PR:Q9D2C9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D2C9; protein.
DR Bgee; ENSMUSG00000028483; Expressed in rostral migratory stream and 257 other tissues.
DR ExpressionAtlas; Q9D2C9; baseline and differential.
DR Genevisible; Q9D2C9; MM.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central.
DR GO; GO:0003681; F:bent DNA binding; IBA:GO_Central.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042795; P:snRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042796; P:snRNA transcription by RNA polymerase III; IBA:GO_Central.
DR InterPro; IPR022042; snRNA-activating_su3.
DR PANTHER; PTHR13421; PTHR13421; 1.
DR Pfam; PF12251; SNAPC3; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..407
FT /note="snRNA-activating protein complex subunit 3"
FT /id="PRO_0000072026"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 255
FT /note="Y -> C (in Ref. 1; BAC27585)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 46277 MW; 8BC79D553C7F5A7D CRC64;
MAEDLQGGGA GGPQHPVPSA SHSSFPEYEL PELHTRVFHV GSFGELWRGR LGAQDLSLSE
PQAAEQPTDG GASNDGFEDA AVASDLGCSL EAAAELRVVC GLDKLRCLGE DEDPEVIPEN
TDLVTLCVRK GLLDYREENI TIDRACRQEI FAYEMESHAL GKKPENPADM IEEGECILSV
NILYPVIFNK HKEHKPYQTM LVLGSQKLTE LRDSICCVSD LQIGGEFSNA PDQAPEHISK
DLYKSAFFYF EGTFYNDRRY PECRDLSRTI IEWSESHDRG YGKFQTARME DFTFNDLHIK
LGFPYLYCHQ GDCEHVVVIT DIRLVHHDDC LDRTLYPLLT KKHWLWTRKC FVCKMYTARW
VTNNDTFAPE DPCFFCDVCF RMLHYDSEGN KLGEFLAYPY VDPGTFN
