ID   SNF7_CRYNB              Reviewed;         220 AA.
AC   P0CR55; Q55V53; Q5KL29;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Vacuolar-sorting protein SNF7;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN   Name=SNF7; Synonyms=VPS32; OrderedLocusNames=CNBC6300;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the sorting and concentration of proteins
CC       resulting in the entry of these proteins into the invaginating vesicles
CC       of the multivesicular body (MVB). Also required for the proteolytic
CC       cleavage of the transcription factor RIM101 in response to alkaline
CC       ambient pH (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: A component of the endosomal sorting required for transport
CC       complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AAEY01000017; EAL21592.1; -; Genomic_DNA.
DR   RefSeq; XP_776239.1; XM_771146.1.
DR   AlphaFoldDB; P0CR55; -.
DR   SMR; P0CR55; -.
DR   EnsemblFungi; AAW42105; AAW42105; CNC00960.
DR   EnsemblFungi; EAL21592; EAL21592; CNBC6300.
DR   GeneID; 4935297; -.
DR   KEGG; cnb:CNBC6300; -.
DR   VEuPathDB; FungiDB:CNBC6300; -.
DR   HOGENOM; CLU_071097_1_1_1; -.
DR   Proteomes; UP000001435; Chromosome 3.
DR   GO; GO:0000815; C:ESCRT III complex; IEA:EnsemblFungi.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR   GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR   GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Endosome; Membrane.
FT   CHAIN           1..220
FT                   /note="Vacuolar-sorting protein SNF7"
FT                   /id="PRO_0000410289"
FT   REGION          175..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          15..86
FT                   /evidence="ECO:0000255"
FT   COILED          153..220
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  24334 MW;  FBDC6DF0091C31BE CRC64;
     MSGWMSYFTG RKDTRESARD AIVGLRQQLL MLEKKEEFLQ KKIEEEMKKA KANATGNKRL
     AMAALRQKKA HENELDRIAG TRLTLETQVN AIESANLNAE TMVAMKKGAD ALKGIHSNLT
     AEGVDATMDK IREQMDLTND ISDAISNPVG MGIVLDEDDL KEELEALEQE QLDDRLAGAD
     RVPSHLPASP VGQTTGRAAV EEDEDDEEAQ LRKLQAELAM