ID   SNET1_CAEEL             Reviewed;         101 AA.
AC   Q11099;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Protein snet-1 {ECO:0000312|WormBase:C02F12.3};
DE   AltName: Full=Suppressor of nep-2 {ECO:0000312|WormBase:C02F12.3};
DE   Flags: Precursor;
GN   Name=snet-1 {ECO:0000312|WormBase:C02F12.3};
GN   ORFNames=C02F12.3 {ECO:0000312|WormBase:C02F12.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=20929849; DOI=10.1126/science.1192020;
RA   Yamada K., Hirotsu T., Matsuki M., Butcher R.A., Tomioka M., Ishihara T.,
RA   Clardy J., Kunitomo H., Iino Y.;
RT   "Olfactory plasticity is regulated by pheromonal signaling in
RT   Caenorhabditis elegans.";
RL   Science 329:1647-1650(2010).
CC   -!- FUNCTION: Negatively regulates chemotaxis and olfactory plasticity
CC       which is the change from positive chemotaxis to dispersal after
CC       prolonged exposure to an odorant. May be down-regulated in response to
CC       pheromone exposure, resulting in promotion of olfactory plasticity.
CC       {ECO:0000269|PubMed:20929849, ECO:0000303|PubMed:20929849}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20929849}.
CC       Perikaryon {ECO:0000269|PubMed:20929849}. Note=May be transported to
CC       neurites in an unc-104-dependent manner and secreted from there.
CC       {ECO:0000303|PubMed:20929849}.
CC   -!- TISSUE SPECIFICITY: Expressed in coelomocytes, the ASK sensory neurons
CC       and interneurons AIB, AIM and PVQ. {ECO:0000269|PubMed:20929849}.
CC   -!- PTM: May be degraded by the nep-2 peptidase.
CC       {ECO:0000303|PubMed:20929849}.
CC   -!- DISRUPTION PHENOTYPE: Suppresses the olfactory plasticity defect in
CC       nep-2 mutants, which are defective in the plasticity of chemotaxis to
CC       benzaldehyde. Double mutants of snet-1 and daf-22 suppress the daf-22
CC       mutant olfactory plasticity-defective phenotype to levels similar to
CC       wild-type. {ECO:0000269|PubMed:20929849}.
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DR   EMBL; FO080254; CCD62374.1; -; Genomic_DNA.
DR   RefSeq; NP_508631.2; NM_076230.6.
DR   AlphaFoldDB; Q11099; -.
DR   STRING; 6239.C02F12.3.1; -.
DR   EPD; Q11099; -.
DR   PaxDb; Q11099; -.
DR   PeptideAtlas; Q11099; -.
DR   EnsemblMetazoa; C02F12.3.1; C02F12.3.1; WBGene00015354.
DR   EnsemblMetazoa; C02F12.3.2; C02F12.3.2; WBGene00015354.
DR   UCSC; C02F12.3.1; c. elegans.
DR   WormBase; C02F12.3; CE30849; WBGene00015354; snet-1.
DR   eggNOG; ENOG502TI0I; Eukaryota.
DR   HOGENOM; CLU_2294265_0_0_1; -.
DR   InParanoid; Q11099; -.
DR   OMA; RSGGHPM; -.
DR   OrthoDB; 1602243at2759; -.
DR   PRO; PR:Q11099; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00015354; Expressed in larva and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0050920; P:regulation of chemotaxis; IMP:UniProtKB.
DR   GO; GO:0090328; P:regulation of olfactory learning; IMP:UniProtKB.
DR   GO; GO:0019236; P:response to pheromone; IMP:UniProtKB.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Pheromone response; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..101
FT                   /note="Protein snet-1"
FT                   /id="PRO_0000014275"
SQ   SEQUENCE   101 AA;  11543 MW;  44C428A4ECCC1162 CRC64;
     MARFTPLLMI LLALVPLYYS LDCRKFSFAP ACRGIMLKRS GGHPMIAEQQ PMIDNAKARE
     VQMMELLIRN IEDEALIANS DCVSMSWLRD RLVNAKNEMP Q