SMR8_ARATH
ID SMR8_ARATH Reviewed; 110 AA.
AC Q9SAD3;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Cyclin-dependent protein kinase inhibitor SMR8 {ECO:0000303|PubMed:20706207, ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
DE AltName: Full=Protein SIAMESE-RELATED 8 {ECO:0000303|PubMed:20706207, ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN Name=SMR8 {ECO:0000303|PubMed:20706207, ECO:0000303|PubMed:24399300,
GN ECO:0000303|PubMed:26546445};
GN OrderedLocusNames=At1g10690 {ECO:0000312|Araport:AT1G10690};
GN ORFNames=T16B5.17 {ECO:0000312|EMBL:AAD31344.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH CDKA-1 AND D-TYPE CYCLINS, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20706207; DOI=10.1038/msb.2010.53;
RA Van Leene J., Hollunder J., Eeckhout D., Persiau G., Van De Slijke E.,
RA Stals H., Van Isterdael G., Verkest A., Neirynck S., Buffel Y., De Bodt S.,
RA Maere S., Laukens K., Pharazyn A., Ferreira P.C.G., Eloy N., Renne C.,
RA Meyer C., Faure J.-D., Steinbrenner J., Beynon J., Larkin J.C.,
RA Van de Peer Y., Hilson P., Kuiper M., De Veylder L., Van Onckelen H.,
RA Inze D., Witters E., De Jaeger G.;
RT "Targeted interactomics reveals a complex core cell cycle machinery in
RT Arabidopsis thaliana.";
RL Mol. Syst. Biol. 6:397-397(2010).
RN [5]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24399300; DOI=10.1105/tpc.113.118943;
RA Yi D., Alvim Kamei C.L., Cools T., Vanderauwera S., Takahashi N.,
RA Okushima Y., Eekhout T., Yoshiyama K.O., Larkin J., Van den Daele H.,
RA Conklin P., Britt A., Umeda M., De Veylder L.;
RT "The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5
RT and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen
RT species.";
RL Plant Cell 26:296-309(2014).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=26546445; DOI=10.1105/tpc.15.00489;
RA Kumar N., Harashima H., Kalve S., Bramsiepe J., Wang K., Sizani B.L.,
RA Bertrand L.L., Johnson M.C., Faulk C., Dale R., Simmons L.A.,
RA Churchman M.L., Sugimoto K., Kato N., Dasanayake M., Beemster G.,
RA Schnittger A., Larkin J.C.;
RT "Functional conservation in the SIAMESE-RELATED family of cyclin-dependent
RT kinase inhibitors in land plants.";
RL Plant Cell 27:3065-3080(2015).
CC -!- FUNCTION: Probable cyclin-dependent protein kinase (CDK) inhibitor that
CC functions as a repressor of mitosis in the endoreduplication cell
CC cycle. {ECO:0000250|UniProtKB:Q9LZ78}.
CC -!- SUBUNIT: Interacts with CDKA-1 and D-type cyclins (PubMed:20706207).
CC {ECO:0000269|PubMed:20706207}.
CC -!- TISSUE SPECIFICITY: Expressed in the root vascular tissue
CC (PubMed:24399300). {ECO:0000269|PubMed:24399300}.
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DR EMBL; AC007354; AAD31344.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28629.1; -; Genomic_DNA.
DR EMBL; BT012351; AAS77476.1; -; mRNA.
DR EMBL; BT012362; AAS88752.1; -; mRNA.
DR PIR; C86240; C86240.
DR RefSeq; NP_172539.1; NM_100945.3.
DR AlphaFoldDB; Q9SAD3; -.
DR IntAct; Q9SAD3; 9.
DR STRING; 3702.AT1G10690.1; -.
DR PaxDb; Q9SAD3; -.
DR PRIDE; Q9SAD3; -.
DR EnsemblPlants; AT1G10690.1; AT1G10690.1; AT1G10690.
DR GeneID; 837612; -.
DR Gramene; AT1G10690.1; AT1G10690.1; AT1G10690.
DR KEGG; ath:AT1G10690; -.
DR Araport; AT1G10690; -.
DR TAIR; locus:2196459; AT1G10690.
DR eggNOG; ENOG502R1KK; Eukaryota.
DR HOGENOM; CLU_2226943_0_0_1; -.
DR InParanoid; Q9SAD3; -.
DR OMA; KPHHQLD; -.
DR OrthoDB; 1582126at2759; -.
DR PhylomeDB; Q9SAD3; -.
DR PRO; PR:Q9SAD3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SAD3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IEA:InterPro.
DR InterPro; IPR040389; SMR.
DR PANTHER; PTHR33142; PTHR33142; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..110
FT /note="Cyclin-dependent protein kinase inhibitor SMR8"
FT /id="PRO_0000438467"
SQ SEQUENCE 110 AA; 12166 MW; 1088A0D81FDED64C CRC64;
MGYSGKPHHQ LDGEIRESTD GKKWVIAGIP SRSPLKQINL SPGVTVTETE EQDQCPTTPT
AVSVRIPRVP PCPAAPKKRK PSLKCSYVTV TRDYFSPPDL ETVFIQRASY
