SMGC_MOUSE
ID SMGC_MOUSE Reviewed; 733 AA.
AC Q6JHY2; A7UN65; Q3V1B0; Q58E46; Q6IS33; Q7TNU8; Q80ZH6;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Submandibular gland protein C;
DE Flags: Precursor;
GN Name=Muc19; Synonyms=Smgc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND
RP GLYCOSYLATION.
RC STRAIN=C57BL/6J; TISSUE=Submandibular gland;
RX PubMed=15256252; DOI=10.1016/j.gene.2004.03.014;
RA Zinzen K.M., Hand A.R., Yankova M., Ball W.D., Mirels L.;
RT "Molecular cloning and characterization of the neonatal rat and mouse
RT submandibular gland protein SMGC.";
RL Gene 334:23-33(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING (ISOFORMS 1
RP AND 2), AND TISSUE SPECIFICITY.
RC STRAIN=NFS; TISSUE=Sublingual gland;
RX PubMed=15340121; DOI=10.1152/physiolgenomics.00161.2004;
RA Culp D.J., Latchney L.R., Fallon M.A., Denny P.A., Denny P.C.,
RA Couwenhoven R.I., Chuang S.;
RT "The gene encoding mouse Muc19: cDNA, genomic organization and relationship
RT to Smgc.";
RL Physiol. Genomics 19:303-318(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 47-733 (ISOFORM 6), AND NUCLEOTIDE SEQUENCE [LARGE
RP SCALE MRNA] OF 319-733 (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Comment=Isoform 1 and isoform 2-6 share the first 17 amino acid
CC residues that correspond to the signal sequence.;
CC Name=2; Synonyms=Smgc;
CC IsoId=Q6JHY2-1; Sequence=Displayed;
CC Name=1; Synonyms=Mucin-19;
CC IsoId=Q6PZE0-1; Sequence=External;
CC Name=3;
CC IsoId=Q6JHY2-2; Sequence=VSP_034526;
CC Name=4;
CC IsoId=Q6JHY2-3; Sequence=VSP_034524;
CC Name=5; Synonyms=t-Smgc;
CC IsoId=Q6JHY2-4; Sequence=VSP_034523;
CC Name=6;
CC IsoId=Q6JHY2-5; Sequence=VSP_034525;
CC -!- TISSUE SPECIFICITY: Detected in terminal tubule cells of the
CC submandibular gland (at protein level). Expressed in submandibular
CC salivary glands of 3-day-old males but not adults. Expression in adult
CC submandibular glands is restricted to females. Isoform 5 is expressed
CC in both 3-day-old and adult sublingual glands.
CC {ECO:0000269|PubMed:15256252, ECO:0000269|PubMed:15340121}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:15256252}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH55490.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR EMBL; AY459348; AAR23240.1; -; mRNA.
DR EMBL; EU089958; ABU50845.1; -; mRNA.
DR EMBL; AK132579; BAE21241.1; -; mRNA.
DR EMBL; BC049243; AAH49243.1; -; mRNA.
DR EMBL; BC092073; AAH92073.1; -; mRNA.
DR EMBL; BC055490; AAH55490.1; ALT_INIT; mRNA.
DR EMBL; BC069958; AAH69958.1; -; mRNA.
DR CCDS; CCDS27762.1; -. [Q6JHY2-1]
DR RefSeq; NP_945121.1; NM_198927.3. [Q6JHY2-1]
DR AlphaFoldDB; Q6JHY2; -.
DR STRING; 10090.ENSMUSP00000085915; -.
DR GlyGen; Q6JHY2; 10 sites.
DR iPTMnet; Q6JHY2; -.
DR PhosphoSitePlus; Q6JHY2; -.
DR MaxQB; Q6JHY2; -.
DR PaxDb; Q6JHY2; -.
DR PRIDE; Q6JHY2; -.
DR ProteomicsDB; 261265; -. [Q6JHY2-1]
DR ProteomicsDB; 261266; -. [Q6JHY2-2]
DR ProteomicsDB; 261267; -. [Q6JHY2-3]
DR ProteomicsDB; 261268; -. [Q6JHY2-4]
DR ProteomicsDB; 261269; -. [Q6JHY2-5]
DR DNASU; 223809; -.
DR Ensembl; ENSMUST00000088555; ENSMUSP00000085915; ENSMUSG00000047295. [Q6JHY2-1]
DR Ensembl; ENSMUST00000100293; ENSMUSP00000097866; ENSMUSG00000047295. [Q6JHY2-2]
DR Ensembl; ENSMUST00000109277; ENSMUSP00000104900; ENSMUSG00000047295. [Q6JHY2-4]
DR GeneID; 223809; -.
DR KEGG; mmu:223809; -.
DR UCSC; uc007xic.1; mouse. [Q6JHY2-1]
DR UCSC; uc007xid.1; mouse. [Q6JHY2-4]
DR UCSC; uc011zxz.1; mouse. [Q6JHY2-2]
DR UCSC; uc011zya.1; mouse. [Q6JHY2-3]
DR UCSC; uc011zyb.1; mouse. [Q6JHY2-5]
DR CTD; 223809; -.
DR MGI; MGI:1859618; Smgc.
DR VEuPathDB; HostDB:ENSMUSG00000047295; -.
DR GeneTree; ENSGT00680000100886; -.
DR HOGENOM; CLU_407649_0_0_1; -.
DR OMA; DPLMEES; -.
DR PhylomeDB; Q6JHY2; -.
DR BioGRID-ORCS; 223809; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Muc19; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6JHY2; protein.
DR Bgee; ENSMUSG00000047295; Expressed in submandibular gland and 17 other tissues.
DR ExpressionAtlas; Q6JHY2; baseline and differential.
DR Genevisible; Q6JHY2; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..733
FT /note="Submandibular gland protein C"
FT /id="PRO_5000092417"
FT REGION 48..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 447
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 514
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 611
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 686
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 696
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 18..622
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15340121"
FT /id="VSP_034523"
FT VAR_SEQ 231..622
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034524"
FT VAR_SEQ 320..621
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034525"
FT VAR_SEQ 470..502
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034526"
FT CONFLICT 274..276
FT /note="GHS -> DHP (in Ref. 4; AAH92073)"
FT /evidence="ECO:0000305"
FT CONFLICT 629
FT /note="R -> S (in Ref. 4; AAH92073/AAH55490/AAH69958/
FT AAH49243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 733 AA; 74383 MW; 243B1628F29ADF6B CRC64;
MKLILLYLAV VLCFVGKARS FRNGAGFYTS LGGQMRVFDF NKKTLDAKSS GGSKDYNLSD
GGKSNSRKNL SPATGGSATQ QSNLDDSHAP NLGKSETMLS LLGYLGAFRP VLSGLTSLPR
VGGGAHGNIG LRAEISRNGV NLSGDSSARG SLNVNPLSGL STKSGNDATV QGQQAAASGG
SKHNVENSSL STGSATSNKG ADKPSEHLSN LFLKGLKGIV EPITSAAGGS VSSAVENLKA
QIKKFIEPLT EDHGPTSTSA SVSGDSSTSS RLDGHSSDGL SKVSGDDPTV QGHDVAASDG
SKQNVEDSTL STGSATSNEG DDKSSDNSSN TFREDLEKIL EQITSAPGGS VSSAVENLKA
QIKKFIEPLT EDHGPTSTSA SVSGDSSTSS RLDGHSSDGL SKVSGDDPTV QGHDVAASDG
SKQNVEDSTL STGSATSNEG DDKSSDNSSN TFREDLEKIL EQITSAPGGS VSTVNNPDED
RLISIIENLA GHIQQSVTEA SQSAERPNAQ SSNNLSGKLE PKYENPTNGS SSASSADKPY
EEGMRKLLKF LEEQYGQTGT DASVSGMSSE SSRSNVHLSD GFSMESGDDA TVQGQQAAAS
GGPKQNVESS NSSTGSATSN GGGDSNEVRG PSSSAVDSTD SGDRGNLADK QGPGFNGPEG
VGENNGGSFR AGSLDTGSKS DSGSHNLSSG SGSRSNVSTG GEPSDKNEPA DPGVSGRVTC
PTGKTQSGSP SVA
