SKIT4_MOUSE
ID SKIT4_MOUSE Reviewed; 474 AA.
AC A7TZF3; A7TZF4;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Selection and upkeep of intraepithelial T-cells protein 4;
DE Short=Skint-4;
DE Flags: Precursor;
GN Name=Skint4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=18408721; DOI=10.1038/ng.108;
RA Boyden L.M., Lewis J.M., Barbee S.D., Bas A., Girardi M., Hayday A.C.,
RA Tigelaar R.E., Lifton R.P.;
RT "Skint1, the prototype of a newly identified immunoglobulin superfamily
RT gene cluster, positively selects epidermal gammadelta T cells.";
RL Nat. Genet. 40:656-662(2008).
CC -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC cells in the embryonic thymus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A;
CC IsoId=A7TZF3-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=A7TZF3-2; Sequence=VSP_034882;
CC -!- TISSUE SPECIFICITY: Expressed in skin, thymus and, to a lower extent,
CC bladder and testis. {ECO:0000269|PubMed:18408721}.
CC -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC in the D1 region of the chromosome 4.
CC -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
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DR EMBL; EF494897; ABS30719.1; -; mRNA.
DR EMBL; EF494898; ABS30720.1; -; mRNA.
DR CCDS; CCDS84779.1; -. [A7TZF3-1]
DR RefSeq; NP_001334109.1; NM_001347180.1. [A7TZF3-1]
DR AlphaFoldDB; A7TZF3; -.
DR SMR; A7TZF3; -.
DR STRING; 10090.ENSMUSP00000102176; -.
DR GlyGen; A7TZF3; 2 sites.
DR PaxDb; A7TZF3; -.
DR PRIDE; A7TZF3; -.
DR DNASU; 320640; -.
DR Ensembl; ENSMUST00000069769; ENSMUSP00000070676; ENSMUSG00000055960. [A7TZF3-1]
DR Ensembl; ENSMUST00000106564; ENSMUSP00000102174; ENSMUSG00000055960. [A7TZF3-1]
DR Ensembl; ENSMUST00000106565; ENSMUSP00000102175; ENSMUSG00000055960. [A7TZF3-1]
DR GeneID; 320640; -.
DR KEGG; mmu:320640; -.
DR UCSC; uc008udr.1; mouse. [A7TZF3-1]
DR UCSC; uc012diq.1; mouse. [A7TZF3-2]
DR CTD; 320640; -.
DR MGI; MGI:2444425; Skint4.
DR VEuPathDB; HostDB:ENSMUSG00000055960; -.
DR eggNOG; ENOG502SEQH; Eukaryota.
DR GeneTree; ENSGT00940000162562; -.
DR HOGENOM; CLU_013137_8_7_1; -.
DR InParanoid; A7TZF3; -.
DR PhylomeDB; A7TZF3; -.
DR BioGRID-ORCS; 320640; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Skint4; mouse.
DR PRO; PR:A7TZF3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A7TZF3; protein.
DR Bgee; ENSMUSG00000055960; Expressed in zone of skin and 20 other tissues.
DR ExpressionAtlas; A7TZF3; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..474
FT /note="Selection and upkeep of intraepithelial T-cells
FT protein 4"
FT /id="PRO_5000270108"
FT TOPO_DOM 26..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..341
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..420
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 442..474
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..140
FT /note="Ig-like V-type"
FT DOMAIN 141..234
FT /note="Ig-like C1-type"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..122
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 162..216
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 326..408
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034882"
SQ SEQUENCE 474 AA; 54166 MW; F58376F959E18E2D CRC64;
MGATEVLTSY CVVLCLLQMV ALSSGHFTVI GSQRPILATL GGNVELNCQL SPPQQAQHME
IRWFRNRYTQ PVHLYRNGKN LHGETMSKYV ERTELLTDAF NEGKVILRIL NVTVDDGGAY
HCVFKDGEFY EEHITEVKVT ATSSDIQILM HTPNIKGVML ECHSGGWFPQ PHMEWRNSKG
EVIQATSKFH SQDKNKLFNM SMVLFIEASS HRNVICYFQN LVTHQEQSIN IVLSGELFSW
KIVWIMILST ISFVMIDFCM TYCVQQQLIH EESLSTVDND QCESDQSEGT CYKRNYPWII
IAVVPIISVF AIIGVMLFLH LEQRVTILEQ HFELDTLWLE DISVILCVVI VSNINLIPLI
YFRLHEHVPR FKDRSPILNK AVVFLHFIYF SIVCGTILLV HLQLRNKVSI SDSLFSLYNS
WLTDISMILG FLLSIFIVTT IAKSSLFNKK WCIGLCIHMK EAEATGGPCE GEEL
