SIX6_CHICK
ID SIX6_CHICK Reviewed; 246 AA.
AC O93307;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Homeobox protein SIX6;
DE AltName: Full=Optic homeobox 2;
DE AltName: Full=Sine oculis homeobox homolog 6;
DE AltName: Full=Six9 protein;
GN Name=SIX6; Synonyms=OPTX2, SIX9;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryonic retina;
RX PubMed=9724757; DOI=10.1073/pnas.95.18.10643;
RA Toy J., Yang J.-M., Leppert G.S., Sundin O.H.;
RT "The optx2 homeobox gene is expressed in early precursors of the eye and
RT activates retina-specific genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:10643-10648(1998).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=10381575; DOI=10.1016/s0925-4773(99)00017-9;
RA Lopez-Rios J., Gallardo E., Rodriguez de Cordoba S., Bovolenta P.;
RT "Six9 (Optx2), a new member of the Six gene family of transcription
RT factors, is expressed at early stages of vertebrate ocular and pituitary
RT development.";
RL Mech. Dev. 83:155-159(1999).
CC -!- FUNCTION: May be involved in eye development.
CC {ECO:0000303|PubMed:9724757}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: In the developing embryo, expressed in the anterior
CC head-fold, the anterior neural plate and optic vesicle. At later stages
CC expression is maintained in the eye, while brain expression becomes
CC limited. Not expressed in the lens placode.
CC {ECO:0000269|PubMed:10381575, ECO:0000269|PubMed:9724757}.
CC -!- DEVELOPMENTAL STAGE: Expression is first detected in the prechordal
CC mesoderm of stage 4 gastrulas. {ECO:0000269|PubMed:10381575,
CC ECO:0000269|PubMed:9724757}.
CC -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC {ECO:0000305}.
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DR EMBL; AF050131; AAC33851.1; -; mRNA.
DR EMBL; AJ011786; CAA09774.1; -; mRNA.
DR RefSeq; NP_990325.1; NM_204994.1.
DR RefSeq; XP_015142771.1; XM_015287285.1.
DR AlphaFoldDB; O93307; -.
DR BMRB; O93307; -.
DR SMR; O93307; -.
DR STRING; 9031.ENSGALP00000036574; -.
DR GeneID; 395843; -.
DR KEGG; gga:395843; -.
DR CTD; 4990; -.
DR VEuPathDB; HostDB:geneid_395843; -.
DR eggNOG; KOG0775; Eukaryota.
DR HOGENOM; CLU_046914_0_1_1; -.
DR InParanoid; O93307; -.
DR OrthoDB; 1197104at2759; -.
DR PhylomeDB; O93307; -.
DR PRO; PR:O93307; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0001654; P:eye development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031701; SIX1_SD.
DR InterPro; IPR032949; SIX3/SIX6.
DR PANTHER; PTHR10390:SF31; PTHR10390:SF31; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..246
FT /note="Homeobox protein SIX6"
FT /id="PRO_0000049309"
FT DNA_BIND 126..186
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 195..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 27637 MW; 772CE6F607AEB541 CRC64;
MFQLPILNFS PQQVAGVCET LEESGDIERL GRFLWSLPVA PAACEALNKN ESVLRARAIV
AFHTGNYREL YHILENHKFT KESHGKLQAL WLEAHYQEAE KLRGRPLGPV DKYRVRKKFP
LPRTIWDGEQ KTHCFKERTR HLLREWYLQD PYPNPSKKRE LAQATGLTPT QVGNWFKNRR
QRDRAAAAKN RLQQQVLAQG SGRSLQAEEE SGGEAGGAAS SPAVSLSSKA ATSAISITSS
DSECDI
