SHSL1_HUMAN
ID SHSL1_HUMAN Reviewed; 199 AA.
AC Q3SXP7; A6NHP0; A9Z1Z0; Q3SXP8; Q5JZ71; Q9BYB5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein shisa-like-1 {ECO:0000312|HGNC:HGNC:29335};
DE Flags: Precursor;
GN Name=SHISAL1 {ECO:0000312|HGNC:HGNC:29335}; Synonyms=KIAA1644;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-199.
RC TISSUE=Brain;
RX PubMed=11258795; DOI=10.1093/dnares/8.1.1;
RA Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.;
RT "Identification of novel transcribed sequences on human chromosome 22 by
RT expressed sequence tag mapping.";
RL DNA Res. 8:1-9(2001).
CC -!- INTERACTION:
CC Q3SXP7; Q5BKT4: ALG10; NbExp=3; IntAct=EBI-18037857, EBI-13064220;
CC Q3SXP7; Q5I7T1: ALG10B; NbExp=3; IntAct=EBI-18037857, EBI-18075734;
CC Q3SXP7; Q12797-6: ASPH; NbExp=3; IntAct=EBI-18037857, EBI-12092171;
CC Q3SXP7; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-18037857, EBI-12003442;
CC Q3SXP7; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-18037857, EBI-10269179;
CC Q3SXP7; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-18037857, EBI-6166686;
CC Q3SXP7; P29033: GJB2; NbExp=3; IntAct=EBI-18037857, EBI-3905204;
CC Q3SXP7; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-18037857, EBI-11955647;
CC Q3SXP7; O00155: GPR25; NbExp=3; IntAct=EBI-18037857, EBI-10178951;
CC Q3SXP7; P04921: GYPC; NbExp=3; IntAct=EBI-18037857, EBI-7797098;
CC Q3SXP7; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-18037857, EBI-12033434;
CC Q3SXP7; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-18037857, EBI-11956541;
CC Q3SXP7; Q6N075: MFSD5; NbExp=3; IntAct=EBI-18037857, EBI-3920969;
CC Q3SXP7; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-18037857, EBI-2858252;
CC Q3SXP7; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-18037857, EBI-11721828;
CC Q3SXP7; Q01453: PMP22; NbExp=3; IntAct=EBI-18037857, EBI-2845982;
CC Q3SXP7; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-18037857, EBI-2695784;
CC Q3SXP7; Q7RTY0: SLC16A13; NbExp=3; IntAct=EBI-18037857, EBI-12243266;
CC Q3SXP7; Q8TB61: SLC35B2; NbExp=3; IntAct=EBI-18037857, EBI-1054782;
CC Q3SXP7; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-18037857, EBI-10314552;
CC Q3SXP7; Q92504: SLC39A7; NbExp=3; IntAct=EBI-18037857, EBI-1051105;
CC Q3SXP7; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-18037857, EBI-10290130;
CC Q3SXP7; Q9NWF4: SLC52A1; NbExp=3; IntAct=EBI-18037857, EBI-12904614;
CC Q3SXP7; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-18037857, EBI-10694905;
CC Q3SXP7; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-18037857, EBI-2844246;
CC Q3SXP7; E9PQX1: TMEM262; NbExp=3; IntAct=EBI-18037857, EBI-17180389;
CC Q3SXP7; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-18037857, EBI-12038591;
CC Q3SXP7; O95159: ZFPL1; NbExp=3; IntAct=EBI-18037857, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR EMBL; AL022339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL591914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104183; AAI04184.1; -; mRNA.
DR EMBL; BC104184; AAI04185.1; -; mRNA.
DR EMBL; AB051431; BAB33314.1; -; mRNA.
DR CCDS; CCDS43025.1; -.
DR RefSeq; NP_001092764.1; NM_001099294.1.
DR RefSeq; XP_005261847.1; XM_005261790.3.
DR AlphaFoldDB; Q3SXP7; -.
DR SMR; Q3SXP7; -.
DR BioGRID; 124484; 67.
DR IntAct; Q3SXP7; 28.
DR STRING; 9606.ENSP00000370568; -.
DR GlyGen; Q3SXP7; 2 sites.
DR PhosphoSitePlus; Q3SXP7; -.
DR BioMuta; KIAA1644; -.
DR DMDM; 172044643; -.
DR PaxDb; Q3SXP7; -.
DR PeptideAtlas; Q3SXP7; -.
DR PRIDE; Q3SXP7; -.
DR ProteomicsDB; 61819; -.
DR Antibodypedia; 53815; 64 antibodies from 15 providers.
DR DNASU; 85352; -.
DR Ensembl; ENST00000381176.5; ENSP00000370568.4; ENSG00000138944.8.
DR GeneID; 85352; -.
DR KEGG; hsa:85352; -.
DR MANE-Select; ENST00000381176.5; ENSP00000370568.4; NM_001099294.2; NP_001092764.1.
DR UCSC; uc003bet.3; human.
DR CTD; 85352; -.
DR DisGeNET; 85352; -.
DR GeneCards; SHISAL1; -.
DR HGNC; HGNC:29335; SHISAL1.
DR HPA; ENSG00000138944; Tissue enhanced (brain, endometrium, smooth muscle).
DR neXtProt; NX_Q3SXP7; -.
DR OpenTargets; ENSG00000138944; -.
DR PharmGKB; PA164721896; -.
DR VEuPathDB; HostDB:ENSG00000138944; -.
DR eggNOG; ENOG502R0N8; Eukaryota.
DR GeneTree; ENSGT00390000006791; -.
DR HOGENOM; CLU_089343_0_0_1; -.
DR InParanoid; Q3SXP7; -.
DR OMA; ICRVYLA; -.
DR OrthoDB; 1351441at2759; -.
DR PhylomeDB; Q3SXP7; -.
DR TreeFam; TF331539; -.
DR PathwayCommons; Q3SXP7; -.
DR SignaLink; Q3SXP7; -.
DR BioGRID-ORCS; 85352; 12 hits in 1069 CRISPR screens.
DR ChiTaRS; KIAA1644; human.
DR GenomeRNAi; 85352; -.
DR Pharos; Q3SXP7; Tdark.
DR PRO; PR:Q3SXP7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q3SXP7; protein.
DR Bgee; ENSG00000138944; Expressed in lateral nuclear group of thalamus and 147 other tissues.
DR Genevisible; Q3SXP7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395; PTHR31395; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..199
FT /note="Protein shisa-like-1"
FT /id="PRO_0000318951"
FT TOPO_DOM 26..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 146..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 197
FT /note="S -> L (in Ref. 2; AAI04185)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 22573 MW; 55C8E5B55D3B60F6 CRC64;
MTSCGQQSLN VLAVLFSLLF SAVLSAHFRV CEPYTDHKGR YHFGFHCPRL SDNKTFILCC
HHNNTVFKYC CNETEFQAVM QANLTASSEG YMHNNYTALL GVWIYGFFVL MLLVLDLLYY
SAMNYDICKV YLARWGIQGR WMKQDPRRWG NPARAPRPGQ RAPQPQPPPG PLPQAPQAVH
TLRGDAHSPP LMTFQSSSA
