SHSA4_HUMAN
ID SHSA4_HUMAN Reviewed; 197 AA.
AC Q96DD7; B4DFI0; B7ZAJ7; Q5VUU1; Q6P711; Q6UWY7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein shisa-4;
DE AltName: Full=Transmembrane protein 58;
DE Flags: Precursor;
GN Name=SHISA4; Synonyms=C1orf40, TMEM58; ORFNames=UNQ583/PRO1153;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-159.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-159.
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Kidney;
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-159.
RC TISSUE=Brain, Kidney, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96DD7; O95406: CNIH1; NbExp=3; IntAct=EBI-18035902, EBI-12172273;
CC Q96DD7; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-18035902, EBI-2680384;
CC Q96DD7; Q6ICB0: DESI1; NbExp=3; IntAct=EBI-18035902, EBI-2806959;
CC Q96DD7; P21145: MAL; NbExp=3; IntAct=EBI-18035902, EBI-3932027;
CC Q96DD7; O43765: SGTA; NbExp=3; IntAct=EBI-18035902, EBI-347996;
CC Q96DD7; Q86UF1: TSPAN33; NbExp=3; IntAct=EBI-18035902, EBI-12045841;
CC Q96DD7; Q13404: UBE2V1; NbExp=3; IntAct=EBI-18035902, EBI-1050671;
CC Q96DD7; O75841: UPK1B; NbExp=3; IntAct=EBI-18035902, EBI-12237619;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH09558.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY358589; AAQ88952.1; -; mRNA.
DR EMBL; AK294106; BAG57441.1; -; mRNA.
DR EMBL; AK316312; BAH14683.1; -; mRNA.
DR EMBL; AL513217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009558; AAH09558.1; ALT_INIT; mRNA.
DR EMBL; BC061908; AAH61908.1; -; mRNA.
DR EMBL; BC104444; AAI04445.1; -; mRNA.
DR EMBL; BC104445; AAI04446.1; -; mRNA.
DR EMBL; BC111855; AAI11856.1; -; mRNA.
DR CCDS; CCDS1416.1; -.
DR RefSeq; NP_937792.2; NM_198149.2.
DR RefSeq; XP_016855908.1; XM_017000419.1.
DR AlphaFoldDB; Q96DD7; -.
DR SMR; Q96DD7; -.
DR BioGRID; 127204; 10.
DR IntAct; Q96DD7; 11.
DR MINT; Q96DD7; -.
DR STRING; 9606.ENSP00000355064; -.
DR PhosphoSitePlus; Q96DD7; -.
DR BioMuta; SHISA4; -.
DR DMDM; 313104251; -.
DR jPOST; Q96DD7; -.
DR MassIVE; Q96DD7; -.
DR MaxQB; Q96DD7; -.
DR PaxDb; Q96DD7; -.
DR PeptideAtlas; Q96DD7; -.
DR PRIDE; Q96DD7; -.
DR ProteomicsDB; 76282; -.
DR Antibodypedia; 65062; 60 antibodies from 21 providers.
DR DNASU; 149345; -.
DR Ensembl; ENST00000362011.7; ENSP00000355064.7; ENSG00000198892.7.
DR GeneID; 149345; -.
DR KEGG; hsa:149345; -.
DR MANE-Select; ENST00000362011.7; ENSP00000355064.7; NM_198149.3; NP_937792.2.
DR UCSC; uc001gxa.4; human.
DR CTD; 149345; -.
DR DisGeNET; 149345; -.
DR GeneCards; SHISA4; -.
DR HGNC; HGNC:27139; SHISA4.
DR HPA; ENSG00000198892; Tissue enhanced (skeletal).
DR MIM; 617326; gene.
DR neXtProt; NX_Q96DD7; -.
DR OpenTargets; ENSG00000198892; -.
DR PharmGKB; PA162403294; -.
DR VEuPathDB; HostDB:ENSG00000198892; -.
DR eggNOG; ENOG502RY6V; Eukaryota.
DR GeneTree; ENSGT00730000111186; -.
DR HOGENOM; CLU_110080_0_0_1; -.
DR InParanoid; Q96DD7; -.
DR OMA; NPGFNCE; -.
DR OrthoDB; 1429667at2759; -.
DR PhylomeDB; Q96DD7; -.
DR TreeFam; TF332572; -.
DR PathwayCommons; Q96DD7; -.
DR SignaLink; Q96DD7; -.
DR BioGRID-ORCS; 149345; 10 hits in 1069 CRISPR screens.
DR ChiTaRS; SHISA4; human.
DR GenomeRNAi; 149345; -.
DR Pharos; Q96DD7; Tdark.
DR PRO; PR:Q96DD7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96DD7; protein.
DR Bgee; ENSG00000198892; Expressed in temporal lobe and 97 other tissues.
DR Genevisible; Q96DD7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395; PTHR31395; 1.
DR Pfam; PF13908; Shisa; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..197
FT /note="Protein shisa-4"
FT /id="PRO_0000254090"
FT TOPO_DOM 28..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 159
FT /note="I -> M (in dbSNP:rs2250377)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_028811"
SQ SEQUENCE 197 AA; 21522 MW; D2D8DDB195D6AD8A CRC64;
MPPAGLRRAA PLTAIALLVL GAPLVLAGED CLWYLDRNGS WHPGFNCEFF TFCCGTCYHR
YCCRDLTLLI TERQQKHCLA FSPKTIAGIA SAVILFVAVV ATTICCFLCS CCYLYRRRQQ
LQSPFEGQEI PMTGIPVQPV YPYPQDPKAG PAPPQPGFIY PPSGPAPQYP LYPAGPPVYN
PAAPPPYMPP QPSYPGA
