ID   SGO1_CANGA              Reviewed;         603 AA.
AC   Q6FMT2;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Shugoshin;
GN   Name=SGO1; OrderedLocusNames=CAGL0K05445g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a central role in chromosome cohesion during cell
CC       division by preventing premature dissociation of cohesin complex from
CC       centromeres after prophase, when most of cohesin complex dissociates
CC       from chromosomes arms. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shugoshin family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61423.1; -; Genomic_DNA.
DR   RefSeq; XP_448462.1; XM_448462.1.
DR   AlphaFoldDB; Q6FMT2; -.
DR   SMR; Q6FMT2; -.
DR   STRING; 5478.XP_448462.1; -.
DR   EnsemblFungi; CAG61423; CAG61423; CAGL0K05445g.
DR   GeneID; 2890486; -.
DR   KEGG; cgr:CAGL0K05445g; -.
DR   CGD; CAL0134399; CAGL0K05445g.
DR   VEuPathDB; FungiDB:CAGL0K05445g; -.
DR   eggNOG; ENOG502QSMK; Eukaryota.
DR   HOGENOM; CLU_019322_0_0_1; -.
DR   InParanoid; Q6FMT2; -.
DR   OMA; SKIKHSM; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0000776; C:kinetochore; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034508; P:centromere complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0070199; P:establishment of protein localization to chromosome; IEA:EnsemblFungi.
DR   GO; GO:0051383; P:kinetochore organization; IEA:EnsemblFungi.
DR   GO; GO:0034090; P:maintenance of meiotic sister chromatid cohesion; IEA:EnsemblFungi.
DR   GO; GO:0051757; P:meiotic sister chromatid separation; IEA:EnsemblFungi.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IEA:EnsemblFungi.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0034096; P:positive regulation of maintenance of meiotic sister chromatid cohesion; IEA:EnsemblFungi.
DR   GO; GO:0031134; P:sister chromatid biorientation; IEA:EnsemblFungi.
DR   InterPro; IPR011515; Shugoshin_C.
DR   InterPro; IPR011516; Shugoshin_N.
DR   Pfam; PF07557; Shugoshin_C; 1.
DR   Pfam; PF07558; Shugoshin_N; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..603
FT                   /note="Shugoshin"
FT                   /id="PRO_0000055446"
FT   REGION          112..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          11..74
FT                   /evidence="ECO:0000255"
FT   COILED          304..325
FT                   /evidence="ECO:0000255"
FT   COILED          431..451
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        123..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..482
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   603 AA;  68724 MW;  DD5BC8C6A9417AAB CRC64;
     MSNLYSAGTP HIQELQNILD SQQEEWAAIK ENYTTQNSLI AKENCTLKMK LSELENKVSQ
     LIRENVQLRS QVSLNKLEFQ NKLASQINVL ENGVIQRLEE VLYMFDSIRK KESLPSRPTS
     TNETVDRIKK RRQSNEEARN RRRSRSVSTG SAHSTSSMKR RSSTFGEDLI DASIKRALDN
     AQSNSLQTSD TLRLSELPGL NEIDTNNVNN DNLLSPIPHK KRKSNRRKSI YVPELPKPNN
     EPLMENTIEQ QENICSESLI QEGEQSEKLG ENLDADQSHV EDQSFSFTNS VLEYSIPEEN
     TLPKQDILDE TEKRDTAVNQ KKKLEIFHDP PVEELSSSKN EKPPENSITN DPAFITVTGN
     NKVKHSMKSR KPKKNKGSVD ESMPCTQSTE SVDFDRPRRT RGKTVDYRLP SLRAKMRRPT
     EKLVDATTTV NIQDLQVKYK KSKKVLEKEL KTDMKAMKSP KKNEKTFESG TIFKKISRDN
     ESRPSSTHST SSVDAECSHN NSHSENINSS INDTTHSSFN NSTKSVLSDI TNISKNKQQQ
     KTKKLLKTAI INDIYDDKTK NAQKTVSFRV NEDDLSVFDL IQHNDTNKSS PKTYRSRSRK
     NKA