SFT2C_HUMAN
ID SFT2C_HUMAN Reviewed; 215 AA.
AC Q587I9; Q8N2P9;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Vesicle transport protein SFT2C;
DE AltName: Full=SFT2 domain-containing protein 3;
GN Name=SFT2D3 {ECO:0000312|HGNC:HGNC:28767};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:BAC11053.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:BAC11053.1};
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [2] {ECO:0000312|EMBL:AAX82032.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- FUNCTION: May be involved in fusion of retrograde transport vesicles
CC derived from an endocytic compartment with the Golgi complex.
CC {ECO:0000250|UniProtKB:P38166}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SFT2 family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK074549; BAC11053.1; -; mRNA.
DR EMBL; AC006011; AAX82032.1; -; Genomic_DNA.
DR CCDS; CCDS2149.1; -.
DR RefSeq; NP_116129.3; NM_032740.3.
DR AlphaFoldDB; Q587I9; -.
DR BioGRID; 124284; 16.
DR IntAct; Q587I9; 1.
DR STRING; 9606.ENSP00000310803; -.
DR iPTMnet; Q587I9; -.
DR PhosphoSitePlus; Q587I9; -.
DR SwissPalm; Q587I9; -.
DR BioMuta; SFT2D3; -.
DR DMDM; 74721667; -.
DR EPD; Q587I9; -.
DR jPOST; Q587I9; -.
DR MassIVE; Q587I9; -.
DR MaxQB; Q587I9; -.
DR PaxDb; Q587I9; -.
DR PeptideAtlas; Q587I9; -.
DR PRIDE; Q587I9; -.
DR ProteomicsDB; 62599; -.
DR Antibodypedia; 47566; 111 antibodies from 21 providers.
DR DNASU; 84826; -.
DR Ensembl; ENST00000310981.6; ENSP00000310803.3; ENSG00000173349.6.
DR GeneID; 84826; -.
DR KEGG; hsa:84826; -.
DR MANE-Select; ENST00000310981.6; ENSP00000310803.3; NM_032740.4; NP_116129.3.
DR UCSC; uc002tpf.4; human.
DR CTD; 84826; -.
DR DisGeNET; 84826; -.
DR GeneCards; SFT2D3; -.
DR HGNC; HGNC:28767; SFT2D3.
DR HPA; ENSG00000173349; Low tissue specificity.
DR neXtProt; NX_Q587I9; -.
DR OpenTargets; ENSG00000173349; -.
DR PharmGKB; PA142670929; -.
DR VEuPathDB; HostDB:ENSG00000173349; -.
DR eggNOG; ENOG502QV5D; Eukaryota.
DR GeneTree; ENSGT00390000018525; -.
DR HOGENOM; CLU_099529_3_1_1; -.
DR InParanoid; Q587I9; -.
DR OMA; SGFSWPW; -.
DR OrthoDB; 1371944at2759; -.
DR PhylomeDB; Q587I9; -.
DR TreeFam; TF313609; -.
DR PathwayCommons; Q587I9; -.
DR SignaLink; Q587I9; -.
DR BioGRID-ORCS; 84826; 15 hits in 1025 CRISPR screens.
DR ChiTaRS; SFT2D3; human.
DR GenomeRNAi; 84826; -.
DR Pharos; Q587I9; Tdark.
DR PRO; PR:Q587I9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q587I9; protein.
DR Bgee; ENSG00000173349; Expressed in ileal mucosa and 112 other tissues.
DR Genevisible; Q587I9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR InterPro; IPR011691; Vesicle_transpt_SFT2.
DR PANTHER; PTHR23137; PTHR23137; 1.
DR Pfam; PF04178; Got1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..215
FT /note="Vesicle transport protein SFT2C"
FT /id="PRO_0000238613"
FT TOPO_DOM 1..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..107
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..166
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 38
FT /note="R -> G (in dbSNP:rs10206957)"
FT /id="VAR_026558"
SQ SEQUENCE 215 AA; 21790 MW; D8E02002ACA8650C CRC64;
MADLHRQLQE YLAQGKAGGP AAAEPLLAAE KAEEPGDRPA EEWLGRAGLR WTWARSPAES
AAAGLTCLPS VTRGQRLAAG GGCLLLAALC FGLAALYAPV LLLRARKFAL LWSLGSALAL
AGSALLRGGA ACGRLLRCEE APSRPALLYM AALGATLFAA LGLRSTLLTV LGAGAQVAAL
LAALVGLLPW GGGTALRLAL GRLGRGAGLA KVLPV
