BEX6_MOUSE
ID BEX6_MOUSE Reviewed; 114 AA.
AC Q3TZW7; A2RSJ0;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein BEX6;
DE AltName: Full=Brain-expressed X-linked protein 6 homolog;
GN Name=Bex6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEGRADATION BY THE
RP PROTEASOME.
RC STRAIN=C57BL/6J;
RX PubMed=15958283; DOI=10.1016/j.gene.2005.05.012;
RA Alvarez E., Zhou W., Witta S.E., Freed C.R.;
RT "Characterization of the Bex gene family in humans, mice, and rats.";
RL Gene 357:18-28(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Egg, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15958283}.
CC -!- PTM: Ubiquitinated (Probable). Degraded by the proteasome.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: The human orthologous protein seems not to exist.
CC -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY833559; AAX40677.1; -; mRNA.
DR EMBL; AK139543; BAE24057.1; -; mRNA.
DR EMBL; AK157452; BAE34090.1; -; mRNA.
DR EMBL; AK163328; BAE37302.1; -; mRNA.
DR EMBL; BC132130; AAI32131.1; -; mRNA.
DR EMBL; BC132132; AAI32133.1; -; mRNA.
DR CCDS; CCDS28116.1; -.
DR RefSeq; NP_001028711.1; NM_001033539.2.
DR AlphaFoldDB; Q3TZW7; -.
DR SMR; Q3TZW7; -.
DR STRING; 10090.ENSMUSP00000097570; -.
DR iPTMnet; Q3TZW7; -.
DR PhosphoSitePlus; Q3TZW7; -.
DR PaxDb; Q3TZW7; -.
DR PRIDE; Q3TZW7; -.
DR Ensembl; ENSMUST00000099990; ENSMUSP00000097570; ENSMUSG00000075269.
DR Ensembl; ENSMUST00000231512; ENSMUSP00000156069; ENSMUSG00000075269.
DR Ensembl; ENSMUST00000231941; ENSMUSP00000156333; ENSMUSG00000075269.
DR GeneID; 328660; -.
DR KEGG; mmu:328660; -.
DR UCSC; uc007yyk.1; mouse.
DR CTD; 328660; -.
DR MGI; MGI:3588247; Bex6.
DR VEuPathDB; HostDB:ENSMUSG00000075269; -.
DR GeneTree; ENSGT00940000162932; -.
DR HOGENOM; CLU_123122_0_0_1; -.
DR InParanoid; Q3TZW7; -.
DR OMA; IPNSHID; -.
DR OrthoDB; 1525516at2759; -.
DR PhylomeDB; Q3TZW7; -.
DR TreeFam; TF337909; -.
DR BioGRID-ORCS; 328660; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q3TZW7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q3TZW7; protein.
DR Bgee; ENSMUSG00000075269; Expressed in cleaving embryo and 37 other tissues.
DR Genevisible; Q3TZW7; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005874; C:microtubule; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0000922; C:spindle pole; ISO:MGI.
DR GO; GO:0043014; F:alpha-tubulin binding; ISO:MGI.
DR GO; GO:0042826; F:histone deacetylase binding; ISO:MGI.
DR GO; GO:0007059; P:chromosome segregation; ISO:MGI.
DR GO; GO:1904428; P:negative regulation of tubulin deacetylation; ISO:MGI.
DR GO; GO:0030334; P:regulation of cell migration; ISO:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISO:MGI.
DR InterPro; IPR007623; BEX.
DR InterPro; IPR021156; TF_A-like/BEX.
DR PANTHER; PTHR13987; PTHR13987; 1.
DR Pfam; PF04538; BEX; 1.
DR PIRSF; PIRSF008633; BEX; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Ubl conjugation.
FT CHAIN 1..114
FT /note="Protein BEX6"
FT /id="PRO_0000229789"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 114 AA; 13353 MW; 206939778CBCB7DD CRC64;
MMSKVKQVIQ DLTVEKDKGG EASRHSEEES HLLEEVETKN PGGYVKRKVR RLVCNFRWPT
PNRHVDHSEG REDAGRFVGQ ETEAKRKSQE QWMRFSKWFL TPESDSHYNL GLIP
