ID   BETI_STRM5              Reviewed;         196 AA.
AC   B4SHW1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=Smal_1834;
OS   Stenotrophomonas maltophilia (strain R551-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas; Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=391008;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R551-3;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Taghavi S.,
RA   Monchy S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of Stenotrophomonas maltophilia R551-3.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. It represses transcription of the choline transporter
CC       BetT and the genes of BetAB involved in the synthesis of glycine
CC       betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway [regulation].
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DR   EMBL; CP001111; ACF51538.1; -; Genomic_DNA.
DR   RefSeq; WP_012510944.1; NC_011071.1.
DR   AlphaFoldDB; B4SHW1; -.
DR   SMR; B4SHW1; -.
DR   STRING; 391008.Smal_1834; -.
DR   EnsemblBacteria; ACF51538; ACF51538; Smal_1834.
DR   KEGG; smt:Smal_1834; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_15_4_6; -.
DR   OMA; DFWSSSM; -.
DR   OrthoDB; 1745184at2; -.
DR   BioCyc; SMAL391008:SMAL_RS09390-MON; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000001867; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..196
FT                   /note="HTH-type transcriptional regulator BetI"
FT                   /id="PRO_1000133669"
FT   DOMAIN          8..68
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ   SEQUENCE   196 AA;  21820 MW;  CE01564C4ADFA911 CRC64;
     MPKKGVEPVR REQLIRATFQ TIDEIGMADA TVATIAKKAG LSSGIVAHYF GDKDGLLNAA
     MRQILRELKE AVARYRADAG DDPRDQLRAI VDGNFDDSQI NGTAMRVWLT FWAASMHQPE
     LARLQRANDQ RLFSNLCHQF NRLLPHPQAR LAARGLAAMI DGLWLRGSLV GGQFNAEKSR
     RIAYGYIDFQ LQAAAL