SCTL2_SALTY
ID SCTL2_SALTY Reviewed; 224 AA.
AC P74853;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=SPI-2 type 3 secretion system stator protein {ECO:0000305};
DE Short=T3SS-2 stator protein {ECO:0000305};
DE AltName: Full=Secretion system apparatus protein SsaK;
GN Name=sctL2 {ECO:0000303|PubMed:9618447};
GN Synonyms=ssaK {ECO:0000303|PubMed:9140973}; OrderedLocusNames=STM1411;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=9140973; DOI=10.1046/j.1365-2958.1997.3271699.x;
RA Hensel M., Shea J.E., Raupach B., Monack D., Falkow S., Gleeson C.,
RA Kubo T., Holden D.W.;
RT "Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding
RT components of the type III secretion apparatus of Salmonella pathogenicity
RT island 2.";
RL Mol. Microbiol. 24:155-167(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP REVIEW, AND NOMENCLATURE.
RX PubMed=9618447; DOI=10.1128/mmbr.62.2.379-433.1998;
RA Hueck C.J.;
RT "Type III protein secretion systems in bacterial pathogens of animals and
RT plants.";
RL Microbiol. Mol. Biol. Rev. 62:379-433(1998).
RN [4]
RP FUNCTION, SUBUNIT, INTERACTION WITH SSAN/SCTN, AND SUBCELLULAR LOCATION.
RX PubMed=24722491; DOI=10.1371/journal.pone.0094347;
RA Yoshida Y., Miki T., Ono S., Haneda T., Ito M., Okada N.;
RT "Functional characterization of the type III secretion ATPase SsaN encoded
RT by Salmonella pathogenicity island 2.";
RL PLoS ONE 9:e94347-e94347(2014).
RN [5]
RP REVIEW, AND SUBUNIT.
RX PubMed=30107569; DOI=10.1093/femsle/fny201;
RA Wagner S., Grin I., Malmsheimer S., Singh N., Torres-Vargas C.E.,
RA Westerhausen S.;
RT "Bacterial type III secretion systems: a complex device for the delivery of
RT bacterial effector proteins into eukaryotic host cells.";
RL FEMS Microbiol. Lett. 365:0-0(2018).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells (PubMed:24722491). Acts as a regulator of
CC the SsaN/SctN2 ATPase activity (By similarity).
CC {ECO:0000250|UniProtKB:Q01253, ECO:0000269|PubMed:24722491}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle (PubMed:30107569). This
CC subunit is part of the cytosolic complex (PubMed:24722491). Interacts
CC directly with SsaN/SctN2 (T3SS-2 ATPase) (PubMed:24722491).
CC {ECO:0000269|PubMed:24722491, ECO:0000269|PubMed:30107569}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24722491}.
CC Note=Detected in both the soluble and membrane fractions.
CC {ECO:0000269|PubMed:24722491}.
CC -!- SIMILARITY: Belongs to the SctL stator family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA70533.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y09357; CAA70533.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006468; AAL20335.1; -; Genomic_DNA.
DR RefSeq; NP_460376.1; NC_003197.2.
DR RefSeq; WP_000011201.1; NC_003197.2.
DR AlphaFoldDB; P74853; -.
DR SMR; P74853; -.
DR IntAct; P74853; 1.
DR STRING; 99287.STM1411; -.
DR PaxDb; P74853; -.
DR DNASU; 1252929; -.
DR EnsemblBacteria; AAL20335; AAL20335; STM1411.
DR GeneID; 1252929; -.
DR KEGG; stm:STM1411; -.
DR PATRIC; fig|99287.12.peg.1495; -.
DR HOGENOM; CLU_093765_0_0_6; -.
DR OMA; LAQHVHW; -.
DR BioCyc; SENT99287:STM1411-MON; -.
DR PHI-base; PHI:5022; -.
DR PHI-base; PHI:621; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IMP:AgBase.
DR GO; GO:0033644; C:host cell membrane; IMP:AgBase.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR InterPro; IPR012842; T3SS_SctL/SctL2.
DR TIGRFAMs; TIGR02499; HrpE_YscL_not; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Protein transport; Reference proteome; Transport; Virulence.
FT CHAIN 1..224
FT /note="SPI-2 type 3 secretion system stator protein"
FT /id="PRO_0000072203"
SQ SEQUENCE 224 AA; 26293 MW; 533A24B4840302BC CRC64;
MSFTSLPLTE INHKLPARNI IESQWITLQL TLFAQEQQAK RVSHAIVSSA YRKAEKIIRD
AYRYQREQKV EQQQELACLR KNTLEKMEVE WLEQHVKHLQ DDENQFRSLV DHAAHHIKNS
IEQVLLAWFD QQSVDSVMCH RLARQATAMA EEGALYLRIH PEKEALMRET FGKRFTLIIE
PGFSPDQAEL SSTRYAVEFS LSRHFNALLK WLRNGEDKRG SDEY
