ID   SCRN2_MOUSE             Reviewed;         425 AA.
AC   Q8VCA8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Secernin-2;
GN   Name=Scrn2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AK075869; BAC36017.1; -; mRNA.
DR   EMBL; BC021346; AAH21346.1; -; mRNA.
DR   CCDS; CCDS25310.1; -.
DR   RefSeq; NP_666139.1; NM_146027.2.
DR   AlphaFoldDB; Q8VCA8; -.
DR   SMR; Q8VCA8; -.
DR   STRING; 10090.ENSMUSP00000021249; -.
DR   MEROPS; C69.004; -.
DR   iPTMnet; Q8VCA8; -.
DR   PhosphoSitePlus; Q8VCA8; -.
DR   EPD; Q8VCA8; -.
DR   jPOST; Q8VCA8; -.
DR   MaxQB; Q8VCA8; -.
DR   PaxDb; Q8VCA8; -.
DR   PeptideAtlas; Q8VCA8; -.
DR   PRIDE; Q8VCA8; -.
DR   ProteomicsDB; 253426; -.
DR   Antibodypedia; 17779; 169 antibodies from 29 providers.
DR   DNASU; 217140; -.
DR   Ensembl; ENSMUST00000021249; ENSMUSP00000021249; ENSMUSG00000020877.
DR   GeneID; 217140; -.
DR   KEGG; mmu:217140; -.
DR   UCSC; uc007ldk.2; mouse.
DR   CTD; 90507; -.
DR   MGI; MGI:1343092; Scrn2.
DR   VEuPathDB; HostDB:ENSMUSG00000020877; -.
DR   eggNOG; ENOG502QPIA; Eukaryota.
DR   GeneTree; ENSGT00390000013474; -.
DR   HOGENOM; CLU_046840_0_0_1; -.
DR   InParanoid; Q8VCA8; -.
DR   OMA; AKAQGWW; -.
DR   OrthoDB; 322959at2759; -.
DR   PhylomeDB; Q8VCA8; -.
DR   TreeFam; TF323890; -.
DR   BioGRID-ORCS; 217140; 4 hits in 73 CRISPR screens.
DR   PRO; PR:Q8VCA8; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8VCA8; protein.
DR   Bgee; ENSMUSG00000020877; Expressed in right kidney and 228 other tissues.
DR   ExpressionAtlas; Q8VCA8; baseline and differential.
DR   Genevisible; Q8VCA8; MM.
DR   GO; GO:0070004; F:cysteine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR005322; Peptidase_C69.
DR   PANTHER; PTHR12994; PTHR12994; 1.
DR   Pfam; PF03577; Peptidase_C69; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..425
FT                   /note="Secernin-2"
FT                   /id="PRO_0000262553"
FT   ACT_SITE        12
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   425 AA;  46601 MW;  93D08054F815DE88 CRC64;
     MASSSPDAPC SCDCFVSVPP ASAIPAVIFA KNSDRPRDEV QEVVFIPAGT HVPGSRLQCT
     YIEVEQVGKT HAVILSRPSW LWGAEMGANE LGVCIGNEAV WTKEPVGQGE ALLGMDLLRL
     ALERSSTAQE AVHVIAGLLD RYGQGGSCRE DPEPFCYHNT FLLADRTEAW VLETAGSLWA
     AQRIQGGARN ISNQLSIGTD ISAEHPELRS HAKAQGWWTG QGLFDFAEVF SLTQQPVRME
     AAKARFRAGC EMLQRHQGNI TAEVMMGILR DKESGICMDS GGFRTTASMV SVLPQDPTKP
     CVHFLTATPD PSRSVFKPFI FEVGVSQSPQ VLSPTFGAQD PVRILPRFQT RVDRRHSLYR
     GHQAALGLME DEQEQAQQLR KKQQRLEQEG LEALRGLLTG EQTPPAQGLG SLFQAFVERE
     EQAYA