ID   SCR6_ORBFA              Reviewed;          81 AA.
AC   C1KIZ5;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Small cysteine-rich protein 6 {ECO:0000303|PubMed:19283069};
DE            Short=Mfav-SCRiP6 {ECO:0000303|PubMed:19283069};
DE            Short=SCRiP6 {ECO:0000303|PubMed:19283069};
DE   Flags: Precursor;
OS   Orbicella faveolata (Mountainous star coral) (Montastraea faveolata).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Faviina; Merulinidae; Orbicella.
OX   NCBI_TaxID=48498;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19283069; DOI=10.1371/journal.pone.0004865;
RA   Sunagawa S., DeSalvo M.K., Voolstra C.R., Reyes-Bermudez A., Medina M.;
RT   "Identification and gene expression analysis of a taxonomically restricted
RT   cysteine-rich protein family in reef-building corals.";
RL   PLoS ONE 4:E4865-E4865(2009).
CC   -!- FUNCTION: Induces neurotoxic symptoms on zebrafish (By similarity). Has
CC       also been claimed to be implied in calcification, but tests on homolog
CC       proteins suggest that proteins of this family have a neurotoxic
CC       function and not a calcification function (PubMed:19283069).
CC       {ECO:0000250|UniProtKB:C0H691, ECO:0000250|UniProtKB:C0H692,
CC       ECO:0000305|PubMed:19283069}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Nematocyst {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Cnidaria small cysteine-rich protein (SCRiP)
CC       family. {ECO:0000305}.
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DR   EMBL; FJ842108; ACO24836.1; -; mRNA.
DR   AlphaFoldDB; C1KIZ5; -.
DR   SMR; C1KIZ5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Nematocyst; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..25
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434287"
FT   CHAIN           28..81
FT                   /note="Small cysteine-rich protein 6"
FT                   /id="PRO_0000434288"
SQ   SEQUENCE   81 AA;  9331 MW;  B17378F2F98EA3AB CRC64;
     MDTKVACLLL IILGALTVQG AVSGNKRINP LHARQWGEQC MNSMEEFCVP EYSECPPEYE
     PCREDKYCEN DYYCCCRYSG Y