ID   SCR3_ACRMI              Reviewed;          83 AA.
AC   C0H692;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Small cysteine-rich protein 3 {ECO:0000303|PubMed:19283069};
DE            Short=Amil-SCRiP3 {ECO:0000303|PubMed:19283069};
DE            Short=SCRiP3 {ECO:0000303|PubMed:19283069};
DE   Flags: Precursor;
OS   Acropora millepora (Staghorn coral) (Heteropora millepora).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Acroporidae; Acropora.
OX   NCBI_TaxID=45264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19283069; DOI=10.1371/journal.pone.0004865;
RA   Sunagawa S., DeSalvo M.K., Voolstra C.R., Reyes-Bermudez A., Medina M.;
RT   "Identification and gene expression analysis of a taxonomically restricted
RT   cysteine-rich protein family in reef-building corals.";
RL   PLoS ONE 4:E4865-E4865(2009).
RN   [2]
RP   FUNCTION.
RX   PubMed=25757852; DOI=10.1093/molbev/msv050;
RA   Jouiaei M., Sunagar K., Federman Gross A., Scheib H., Alewood P.F.,
RA   Moran Y., Fry B.G.;
RT   "Evolution of an ancient venom: recognition of a novel family of cnidarian
RT   toxins and the common evolutionary origin of sodium and potassium
RT   neurotoxins in sea anemone.";
RL   Mol. Biol. Evol. 32:1598-1610(2015).
CC   -!- FUNCTION: This recombinant protein induces severe neurotoxicity on
CC       zebrafish larvae (Danio rerio) at a concentration of 230 mg/ml, but
CC       does not show toxicity when injected in blowfly larvae (Sarcophaga
CC       falculata). All fish incubated with this protein died within 16 hours
CC       of exposure (PubMed:25757852). Has also been claimed to be implied in
CC       calcification, but this function seems improbable (PubMed:19283069,
CC       PubMed:25757852). {ECO:0000269|PubMed:25757852,
CC       ECO:0000305|PubMed:19283069}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Nematocyst {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- MISCELLANEOUS: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ third party annotation (TPA) entry.
CC   -!- SIMILARITY: Belongs to the Cnidaria small cysteine-rich protein (SCRiP)
CC       family. {ECO:0000305|PubMed:25757852}.
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DR   EMBL; BK006536; DAA06484.1; -; mRNA.
DR   AlphaFoldDB; C0H692; -.
DR   SMR; C0H692; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Nematocyst; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..39
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434299"
FT   CHAIN           42..83
FT                   /note="Small cysteine-rich protein 3"
FT                   /id="PRO_0000434300"
FT   REGION          25..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   83 AA;  9222 MW;  7CD3E04838A69B1F CRC64;
     MGVKLNICLL LLLVAIISSQ GFNLRKKEDS KDEKPFGNYR RGSPCSNYEG SCTPNHIPCP
     PGSHECRQLP GCYPGVERCC CQY