ID   SCR20_NOTSL             Reviewed;         222 AA.
AC   P18425;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=S-crystallin SL20-1;
DE   AltName: Full=Major lens polypeptide;
OS   Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae;
OC   Nototodarus.
OX   NCBI_TaxID=215440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3185725; DOI=10.1038/336086a0;
RA   Tomarev S.I., Zinovieva R.D.;
RT   "Squid major lens polypeptides are homologous to glutathione S-transferases
RT   subunits.";
RL   Nature 336:86-88(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1373730; DOI=10.1016/s0021-9258(18)42486-6;
RA   Tomarev S.I., Zinovieva R.D., Piatigorsky J.;
RT   "Characterization of squid crystallin genes. Comparison with mammalian
RT   glutathione S-transferase genes.";
RL   J. Biol. Chem. 267:8604-8612(1992).
CC   -!- FUNCTION: S-crystallins are structural components of squids and octopi
CC       eye lens. Contains relatively little if any GST activity.
CC   -!- TISSUE SPECIFICITY: Lens.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; M36937; AAA29405.1; -; mRNA.
DR   EMBL; M74315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M74316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M74317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M74318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M74319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M74320; AAA29402.1; -; Genomic_DNA.
DR   PIR; S06442; S06442.
DR   AlphaFoldDB; P18425; -.
DR   SMR; P18425; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR003083; S-crystallin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF14497; GST_C_3; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01269; SCRYSTALLIN.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Eye lens protein.
FT   CHAIN           1..222
FT                   /note="S-crystallin SL20-1"
FT                   /id="PRO_0000186002"
FT   DOMAIN          2..80
FT                   /note="GST N-terminal"
FT   DOMAIN          82..222
FT                   /note="GST C-terminal"
FT   CONFLICT        148
FT                   /note="S -> P (in Ref. 2; AAA29402)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   222 AA;  26604 MW;  1D0AD23E54DA99CB CRC64;
     MPNYTLYYFN GRGRAEICRM LMAAAGVQYT DKRFEFNEWD KYRNDMPSMC VPVLDIDGQN
     KMPETMAIAR YLARENGYYG KNNMDMFRID YICDCFYEIL HDYMRYFHTK NGRFMQGSGT
     DMSPDMDPTQ MTSYIQNRYL DTCRRILSFL ERTLEMRNGG KEFFMGDQMM LCDMMCYCCL
     ENPMLEDQTT FNNFPKLMSL WKRVASHPKI TPYLKKRNNT NW