SCR1_SCHPO
ID SCR1_SCHPO Reviewed; 565 AA.
AC O14335;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=DNA-binding protein scr1;
GN Name=scr1; ORFNames=SPBC1D7.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=9535817; DOI=10.1006/bbrc.1998.8406;
RA Tanaka N., Ohuchi N., Mukai Y., Osaka Y., Ohtani Y., Tabuchi M.,
RA Bhuiyan M.S.A., Fukui H., Harashima S., Takegawa K.;
RT "Isolation and characterization of an invertase and its repressor genes
RT from Schizosaccharomyces pombe.";
RL Biochem. Biophys. Res. Commun. 245:246-253(1998).
CC -!- FUNCTION: Involved in carbon catabolite repression. Represses the
CC transcription of various genes including the inv1 gene.
CC {ECO:0000269|PubMed:9535817}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the creA/MIG C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; CU329671; CAB10978.1; -; Genomic_DNA.
DR PIR; T39863; T39863.
DR RefSeq; NP_595717.1; NM_001021615.2.
DR AlphaFoldDB; O14335; -.
DR SMR; O14335; -.
DR BioGRID; 277288; 5.
DR STRING; 4896.SPBC1D7.02c.1; -.
DR iPTMnet; O14335; -.
DR MaxQB; O14335; -.
DR PaxDb; O14335; -.
DR PRIDE; O14335; -.
DR EnsemblFungi; SPBC1D7.02c.1; SPBC1D7.02c.1:pep; SPBC1D7.02c.
DR GeneID; 2540768; -.
DR KEGG; spo:SPBC1D7.02c; -.
DR PomBase; SPBC1D7.02c; scr1.
DR VEuPathDB; FungiDB:SPBC1D7.02c; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_482468_0_0_1; -.
DR InParanoid; O14335; -.
DR OMA; TSLHSMY; -.
DR PRO; PR:O14335; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; EXP:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:PomBase.
DR GO; GO:0000433; P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0061987; P:negative regulation of transcription from RNA polymerase II promoter by glucose; IMP:PomBase.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..565
FT /note="DNA-binding protein scr1"
FT /id="PRO_0000046885"
FT ZN_FING 26..48
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 54..78
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 59713 MW; FE6CCCF7E54A8CDB CRC64;
MSEATTATTT GKPSRSTKNP DAPRPYKCPL CTKAFYRLEH QTRHIRTHTG EKPHVCTFPG
CAKRFSRSDE LTRHARIHTN ANSRRNAAAA AAANNSARSS NSPAGNLEPS TNNAGVHMTN
ASMNPNVNPS YPVFIPQVGM SVAPPVATAA VSMSYPHHYS ASVQQQQATF VSNGQPHNLP
AQAQPATIYG IPDALHTTQN GTTIHVTGTP PGAVSQRSEP DSRLSSMNEM QLLASAAANQ
LDAAPRITPT KSSGVNLMPL SNAPSPPKQM NVVGSLPSSS NTSPNHLASV PNRGLTSNSS
TGSFTKYTNG SSNSLYSNSS MQTPYLPSKS NSSTSLHSMY GVGTTAYAPQ SLRYAHYNYL
PYSRPSVSNG FDDDSSSSDF AHFRYQRRSR PVSPCSTAPS SPTFSTRSFS PTPDVTPLVT
PAHSPRLRPM DDPSCVQLPS IRSLSLRPSQ VPLIPPLKCD PNAFSASTPA SGAVSRTPSS
VSLSSLSNVN SSMPHKPASQ SNVGPVRISS NRRSRKFSSS SRVSVSNLLA GSPPSPSSST
KSASSSYSTT TPAFSIGPLT PMTKP
