ID   SCR18_NOTSL             Reviewed;         308 AA.
AC   P27016;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=S-crystallin SL18;
OS   Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae;
OC   Nototodarus.
OX   NCBI_TaxID=215440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1373730; DOI=10.1016/s0021-9258(18)42486-6;
RA   Tomarev S.I., Zinovieva R.D., Piatigorsky J.;
RT   "Characterization of squid crystallin genes. Comparison with mammalian
RT   glutathione S-transferase genes.";
RL   J. Biol. Chem. 267:8604-8612(1992).
CC   -!- FUNCTION: S-crystallins are structural components of squids and octopi
CC       eye lens. Contains relatively little if any GST activity.
CC   -!- TISSUE SPECIFICITY: Lens.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M74326; AAA29404.1; -; mRNA.
DR   PIR; S14892; S14892.
DR   AlphaFoldDB; P27016; -.
DR   SMR; P27016; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR003083; S-crystallin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF14497; GST_C_3; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01269; SCRYSTALLIN.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Eye lens protein.
FT   CHAIN           1..308
FT                   /note="S-crystallin SL18"
FT                   /id="PRO_0000186001"
FT   DOMAIN          2..80
FT                   /note="GST N-terminal"
FT   DOMAIN          185..308
FT                   /note="GST C-terminal"
FT   REGION          165..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  36431 MW;  C97B3793257271B6 CRC64;
     MPKYTLYYFN SRGRAEICRM LFAAANIPYN DVRIDYSEWD IYRSKMPGSC LPVLEINDSI
     QIPQTMAIAR YLARQFGFYG KHHLDMARVD FICDSFYDIF NDYMRMYHDQ KGRVMFELMS
     QMREWYAARN ENSGYEECYM QPSMAPSAQM SQEVDNSDTL ADCSEMRSQD SMVEPPSQKL
     SPELESQSSL CSERPQCGPP DPMMGSDFER LSFNEGRMLE MRRRYDETCR RVLPFLEGTL
     KQRYGGDRYF MGEYMTMCDL MCYCALENPL LDNAYLLHPY PKLRGLRDRV SRNQRINSYF
     TLRNYTDF