ID   SCP_LYMST               Reviewed;         136 AA.
AC   O97374;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Small cardioactive peptides;
DE   Contains:
DE     RecName: Full=Small cardioactive peptide B;
DE              Short=SCP B;
DE              Short=SCPb;
DE   Contains:
DE     RecName: Full=Small cardioactive peptide A;
DE              Short=SCP A;
DE              Short=SCPa;
DE   Flags: Precursor;
GN   Name=SCP;
OS   Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Lymnaeidae; Lymnaea.
OX   NCBI_TaxID=6523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10051766; DOI=10.1046/j.1460-9568.1999.00472.x;
RA   Perry S.J., Dobbins A.C., Schofield M.G., Piper M.R., Benjamin P.R.;
RT   "Small cardioactive peptide gene: structure, expression and mass
RT   spectrometric analysis reveals a complex pattern of co-transmitters in a
RT   snail feeding neuron.";
RL   Eur. J. Neurosci. 11:655-662(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AMIDATION AT MET-33
RP   AND MET-44, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=9485334; DOI=10.1021/bi971848b;
RA   Jimenez C.R., Li K.W., Dreisewerd K., Spijker S., Kingston R.,
RA   Bateman R.H., Burlingame A.L., Smit A.B., Van Minnen J., Geraerts W.P.;
RT   "Direct mass spectrometric peptide profiling and sequencing of single
RT   neurons reveals differential peptide patterns in a small neuronal
RT   network.";
RL   Biochemistry 37:2070-2076(1998).
CC   -!- FUNCTION: The cardioactive peptides enhance the contractions of the
CC       auricle in vitro.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the SCP family. {ECO:0000305}.
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DR   EMBL; AF056941; AAC99318.1; -; mRNA.
DR   EMBL; AF157552; AAD40954.1; -; mRNA.
DR   AlphaFoldDB; O97374; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         25..33
FT                   /note="Small cardioactive peptide B"
FT                   /id="PRO_0000001878"
FT   PEPTIDE         36..44
FT                   /note="Small cardioactive peptide A"
FT                   /id="PRO_0000001879"
FT   PROPEP          47..136
FT                   /note="Carboxy-terminal peptide"
FT                   /id="PRO_0000001880"
FT   MOD_RES         33
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:9485334"
FT   MOD_RES         44
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:9485334"
SQ   SEQUENCE   136 AA;  14809 MW;  6C64BC6F82CEE1B3 CRC64;
     MEITLPRVSL SLAVLLVIVC SVDAQNYLAF PRMGRSGYLA FPRMGRSHFK SETSADVTGC
     CGVGIKNEFL IGQDGKEEIR SACGARADCC EGLKEVVDQK NDGVYFSMCV PDITFAQASS
     VRSSEVFNKL KSLLEK