ID   SCP_HCMVM               Reviewed;          75 AA.
AC   F5HEN7;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 30.
DE   RecName: Full=Small capsomere-interacting protein {ECO:0000255|HAMAP-Rule:MF_04021};
GN   Name=SCP {ECO:0000255|HAMAP-Rule:MF_04021}; OrderedLocusNames=UL48A;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=8764088; DOI=10.1128/jvi.70.8.5680-5683.1996;
RA   Gibson W., Clopper K.S., Britt W.J., Baxter M.K.;
RT   "Human cytomegalovirus (HCMV) smallest capsid protein identified as product
RT   of short open reading frame located between HCMV UL48 and UL49.";
RL   J. Virol. 70:5680-5683(1996).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=11152518; DOI=10.1128/jvi.75.3.1450-1458.2001;
RA   Borst E.M., Mathys S., Wagner M., Muranyi W., Messerle M.;
RT   "Genetic evidence of an essential role for cytomegalovirus small capsid
RT   protein in viral growth.";
RL   J. Virol. 75:1450-1458(2001).
CC   -!- FUNCTION: Participates in the assembly of the infectious particles by
CC       decorating the outer surface of the capsid shell and thus forming a
CC       layer between the capsid and the tegument. Complexes composed of the
CC       capsid protein VP5 and UL48A assemble together in the host cytoplasm
CC       and are translocated to the nucleus, where they accumulate and
CC       participate in capsid assembly. {ECO:0000250|UniProtKB:P10219,
CC       ECO:0000269|PubMed:11152518, ECO:0000269|PubMed:8764088}.
CC   -!- FUNCTION: Participates in the assembly of the infectious particles by
CC       decorating the outer surface of the capsid shell and thus forming a
CC       layer between the capsid and the tegument. Complexes composed of the
CC       major capsid protein and small capsomere-interacting protein/SCP
CC       assemble together in the host cytoplasm and are translocated to the
CC       nucleus, where they accumulate and participate in capsid assembly.
CC       {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SUBUNIT: Interacts with the major capsid protein/MCP.
CC       {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04021,
CC       ECO:0000269|PubMed:11152518, ECO:0000269|PubMed:8764088}. Host nucleus
CC       {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SIMILARITY: Belongs to the herpesviridae small capsomere-interacting
CC       protein family. {ECO:0000255|HAMAP-Rule:MF_04021}.
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DR   EMBL; AY446894; AAR31612.1; -; Genomic_DNA.
DR   RefSeq; YP_081507.1; NC_006273.2.
DR   SMR; F5HEN7; -.
DR   PRIDE; F5HEN7; -.
DR   DNASU; 3077541; -.
DR   GeneID; 3077541; -.
DR   KEGG; vg:3077541; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; TAS:Reactome.
DR   GO; GO:0016032; P:viral process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04021; HSV_SCP_betahv; 1.
DR   InterPro; IPR031385; HV_small_capsid.
DR   Pfam; PF17086; HV_small_capsid; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..75
FT                   /note="Small capsomere-interacting protein"
FT                   /id="PRO_0000418247"
SQ   SEQUENCE   75 AA;  8495 MW;  318369AADE521528 CRC64;
     MSNTAPGPTV ANKRDEKHRH VVNVVLELPT EISEATHPVL ATMLSKYTRM SSLFNDKCAF
     KLDLLRMIAV SRTRR