ID   SCP_HCMVA               Reviewed;          75 AA.
AC   Q7M6N6;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Small capsomere-interacting protein {ECO:0000255|HAMAP-Rule:MF_04021};
GN   Name=SCP {ECO:0000255|HAMAP-Rule:MF_04021}; OrderedLocusNames=UL48A;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
CC   -!- FUNCTION: Participates in the assembly of the infectious particles by
CC       decorating the outer surface of the capsid shell and thus forming a
CC       layer between the capsid and the tegument. Complexes composed of the
CC       major capsid protein and small capsomere-interacting protein/SCP
CC       assemble together in the host cytoplasm and are translocated to the
CC       nucleus, where they accumulate and participate in capsid assembly.
CC       {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SUBUNIT: Interacts with the major capsid protein/MCP.
CC       {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04021}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04021}.
CC   -!- SIMILARITY: Belongs to the herpesviridae small capsomere-interacting
CC       protein family. {ECO:0000255|HAMAP-Rule:MF_04021}.
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DR   EMBL; X17403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK000394; DAA00152.1; -; Genomic_DNA.
DR   PDB; 5VKU; EM; 3.90 A; Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f=1-75.
DR   PDB; 7ET3; EM; 4.20 A; R/S/T/i/j=1-75.
DR   PDB; 7LIV; EM; 3.60 A; D/E/Z=1-75.
DR   PDBsum; 5VKU; -.
DR   PDBsum; 7ET3; -.
DR   PDBsum; 7LIV; -.
DR   SMR; Q7M6N6; -.
DR   IntAct; Q7M6N6; 1.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0016032; P:viral process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04021; HSV_SCP_betahv; 1.
DR   InterPro; IPR031385; HV_small_capsid.
DR   Pfam; PF17086; HV_small_capsid; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..75
FT                   /note="Small capsomere-interacting protein"
FT                   /id="PRO_0000115326"
SQ   SEQUENCE   75 AA;  8481 MW;  F28369AADE52153A CRC64;
     MSNTAPGPTV ANKRDEKHRH VVNVVLELPT EISEATHPVL ATMLSKYTRM SSLFNDKCAF
     KLDLLRMVAV SRTRR