ID   SCPRP_OCTVU             Reviewed;         106 AA.
AC   Q2V2G5;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Small cardioactive peptide-related peptide {ECO:0000312|EMBL:BAE66649.1};
DE            Short=oct-SCPRP {ECO:0000303|PubMed:16443307};
DE   Flags: Precursor;
GN   Name=SCPRP {ECO:0000303|PubMed:16443307};
OS   Octopus vulgaris (Common octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=6645;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAE66649.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 43-52, FUNCTION, TISSUE
RP   SPECIFICITY, AMIDATION AT GLN-52, AND MASS SPECTROMETRY.
RC   TISSUE=Brain {ECO:0000269|PubMed:16443307};
RX   PubMed=16443307; DOI=10.1016/j.peptides.2005.12.006;
RA   Kanda A., Minakata H.;
RT   "Isolation and characterization of a novel small cardioactive peptide-
RT   related peptide from the brain of Octopus vulgaris.";
RL   Peptides 27:1755-1761(2006).
CC   -!- FUNCTION: Evokes contractions in the radula protractor muscle, and may
CC       regulate feeding behavior and gut motility by controlling muscle
CC       contraction of the buccal mass. {ECO:0000269|PubMed:16443307}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09892}.
CC   -!- TISSUE SPECIFICITY: Expression is seen in the peripheral and central
CC       nervous systems in tissues such as the brain, the inferior buccal
CC       ganglion, the gastric ganglion, the olfactory lobe, the peduncle lobe
CC       and the optic lobe. Expression in the brain is distributed in the
CC       median inferior frontal lobe, the superior buccal lobe, the
CC       prebranchial lobe and the pedal lobe. Not expressed in the vasomotor
CC       lobe or the palliovisceral lobe that controls the cardiac system.
CC       {ECO:0000269|PubMed:16443307}.
CC   -!- MASS SPECTROMETRY: Mass=1117.6; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16443307};
CC   -!- SIMILARITY: Belongs to the SCP family. {ECO:0000269|PubMed:16443307,
CC       ECO:0000305}.
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DR   EMBL; AB198190; BAE66649.1; -; mRNA.
DR   AlphaFoldDB; Q2V2G5; -.
DR   Proteomes; UP000515154; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..41
FT                   /note="Amino-terminal spacer peptide"
FT                   /evidence="ECO:0000269|PubMed:16443307"
FT                   /id="PRO_0000395442"
FT   PEPTIDE         43..52
FT                   /note="Small cardioactive peptide-related peptide"
FT                   /evidence="ECO:0000269|PubMed:16443307"
FT                   /id="PRO_0000395443"
FT   PROPEP          55..106
FT                   /note="Carboxy-terminal spacer peptide"
FT                   /evidence="ECO:0000269|PubMed:16443307"
FT                   /id="PRO_0000395444"
FT   MOD_RES         52
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000269|PubMed:16443307"
SQ   SEQUENCE   106 AA;  12061 MW;  F4857C3F175AC9F3 CRC64;
     MFCKHLSFVA ITICFLLVLA KTENEIQQKN IKFDQRTWRN MRSNGYLALP RQGRSDNQPD
     YTCCGMPLTK YVGICPIGME CCPGLKKVLQ KSGQRTIYSV CVADAY