ID   SCONB_TALSN             Reviewed;         667 AA.
AC   B8M7Q5;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB;
DE   AltName: Full=Sulfur controller B;
DE   AltName: Full=Sulfur metabolite repression control protein B;
GN   Name=sconB; ORFNames=TSTA_030500;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC       involved in the regulation of sulfur metabolite repression, probably by
CC       mediating the inactivation or degradation of the metR transcription
CC       factor. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC       {ECO:0000305}.
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DR   EMBL; EQ962654; EED19784.1; -; Genomic_DNA.
DR   RefSeq; XP_002480218.1; XM_002480173.1.
DR   AlphaFoldDB; B8M7Q5; -.
DR   SMR; B8M7Q5; -.
DR   STRING; 441959.B8M7Q5; -.
DR   EnsemblFungi; EED19784; EED19784; TSTA_030500.
DR   GeneID; 8101729; -.
DR   VEuPathDB; FungiDB:TSTA_030500; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   HOGENOM; CLU_000288_103_1_1; -.
DR   InParanoid; B8M7Q5; -.
DR   OMA; KMCEQHI; -.
DR   OrthoDB; 617388at2759; -.
DR   PhylomeDB; B8M7Q5; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..667
FT                   /note="Probable E3 ubiquitin ligase complex SCF subunit
FT                   sconB"
FT                   /id="PRO_0000397256"
FT   DOMAIN          182..228
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          347..386
FT                   /note="WD 1"
FT   REPEAT          388..426
FT                   /note="WD 2"
FT   REPEAT          428..464
FT                   /note="WD 3"
FT   REPEAT          466..507
FT                   /note="WD 4"
FT   REPEAT          549..593
FT                   /note="WD 5"
FT   REPEAT          594..633
FT                   /note="WD 6"
FT   REPEAT          636..667
FT                   /note="WD 7"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  74700 MW;  2C62C44840E1381A CRC64;
     MNGSGSTAKE SLFNPTPRKL GLPEDNTMTP YNGVRSIFDN SSGSRQLTDE HTNQERAISK
     AKLADENIAP FLAKHIPSQY APLGADASKT TGPPRPMNSR YCYRHRPDLK CRRQADEPSM
     DHLQWELQSL SQSDQQGIAH VWSLFSAAPA KQRELMLRGI LAQCCFPQLS LISSSVRDLI
     RIDFITALPP EISFKILSYL DTASLCRAAQ VSRAWKCLAD DDVVWHRMCE QHIHRKCTKC
     GWGLPLLERK RLRASKEQIE KRALGVSVAP DSSTIAVQTV DATSGVKRTA EDLEGSDSQV
     VKRQRLPTED TELHRTNVRP WKDVYKDRFK VGTNWKYGRC SVKVFKGHTN GVMCLQFEDN
     ILATGSYDMT IKIWDMETGE ELRTLTGHTS GIRCLQFDDT KLISGSIDRT LKVWNWRTGE
     CISTYTGHLG GIIGLHFENS VLASGSIDNT VKIWNFEDKS TFLLRGHSDW VNAVRVDSAS
     RTVLSASDDC TVKLWDLDSK QCIRTFQGHV GQVQQVIPLP KEFEFEEDHD AGHEEDSNAS
     VSGDESPLRQ EPCSPGASFF EGDRPAPPRY ILTSALDSTI RLWETYSGRC LRTFFGHLEG
     VWALSADTLR IVSGAEDRMV KIWDPRTGKC ERTFTGHSGP VTCVGLGDSC FVTGSEDCEV
     RIHSFKN