ID   SCONB_TALMQ             Reviewed;         660 AA.
AC   B6Q4Z5;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB;
DE   AltName: Full=Sulfur controller B;
DE   AltName: Full=Sulfur metabolite repression control protein B;
GN   Name=sconB; ORFNames=PMAA_022220;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC       involved in the regulation of sulfur metabolite repression, probably by
CC       mediating the inactivation or degradation of the metR transcription
CC       factor. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC       {ECO:0000305}.
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DR   EMBL; DS995899; EEA27338.1; -; Genomic_DNA.
DR   RefSeq; XP_002143853.1; XM_002143817.1.
DR   AlphaFoldDB; B6Q4Z5; -.
DR   SMR; B6Q4Z5; -.
DR   STRING; 441960.B6Q4Z5; -.
DR   PRIDE; B6Q4Z5; -.
DR   EnsemblFungi; EEA27338; EEA27338; PMAA_022220.
DR   GeneID; 7021680; -.
DR   KEGG; tmf:PMAA_022220; -.
DR   VEuPathDB; FungiDB:PMAA_022220; -.
DR   HOGENOM; CLU_000288_103_1_1; -.
DR   OrthoDB; 617388at2759; -.
DR   PhylomeDB; B6Q4Z5; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..660
FT                   /note="Probable E3 ubiquitin ligase complex SCF subunit
FT                   sconB"
FT                   /id="PRO_0000397255"
FT   DOMAIN          175..221
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          340..379
FT                   /note="WD 1"
FT   REPEAT          381..419
FT                   /note="WD 2"
FT   REPEAT          421..457
FT                   /note="WD 3"
FT   REPEAT          459..500
FT                   /note="WD 4"
FT   REPEAT          542..586
FT                   /note="WD 5"
FT   REPEAT          587..626
FT                   /note="WD 6"
FT   REPEAT          629..660
FT                   /note="WD 7"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..549
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  74016 MW;  94D0EEEC15AAC584 CRC64;
     MHNENSVLRD AKESLFNPTP RKQGLPEDNT MTPYNGVRSI FDNSSDSHQL TDDHTHQERA
     ISKAKLANEN IAPFLAKHIP SQYAPLGTGI SKSAGPPPRP DLKCRRQADE PSMDHLQWEL
     QSLPQSDQQG IAHVWSLFSA APAKQRELML RGILAQCCFP QLSLISSSVR DLIRIDFITA
     LPPEISFKIL SYLDTASLCR AAQVSRGWKC LADDDVVWHR MCEQHIHRKC TKCGWGLPLL
     ERKRLRASKE QIEKRALGVS VIPEASVTVQ SVDATSGVKR TAEDLEASDS QTVKRQRLPI
     EEDTNIYKTN FRPWKDVYKD RFKVGTNWKY GRCSVKVFKG HTNGVMCLQF EDNILATGSY
     DTTIKIWDME TGEELRTLTG HTSGIRCLQF DETKLISGSI DRTLKVWNWR TGECISTYTG
     HLGGIIGLHF QNSILASGST DKTVKIWNFE DKSTFLLRGH SDWVNAVRVD SCSRTVLSAS
     DDCTVKLWDL DSKQCIRTFQ GHVGQVQQVI PLPREFEFEE GHDASHEEDS NASVSGDESP
     SSQVSCSPTA AFFEGDRPAP PRYILTSALD STIRLWETYT GRCLRTFFGH LEGVWALSAD
     TLRIVSGAED RMVKIWDPRT GKCERTFTGH SGPVTCVGLG DSCFVTGSED CEVRIYSFKN