ID   SCONB_ARTOC             Reviewed;         674 AA.
AC   C5FP68;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB;
DE   AltName: Full=Sulfur controller B;
DE   AltName: Full=Sulfur metabolite repression control protein B;
GN   Name=sconB; ORFNames=MCYG_04203;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC       involved in the regulation of sulfur metabolite repression, probably by
CC       mediating the inactivation or degradation of the metR transcription
CC       factor. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC       {ECO:0000305}.
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DR   EMBL; DS995704; EEQ31384.1; -; Genomic_DNA.
DR   RefSeq; XP_002846466.1; XM_002846420.1.
DR   AlphaFoldDB; C5FP68; -.
DR   SMR; C5FP68; -.
DR   STRING; 63405.XP_002846466.1; -.
DR   EnsemblFungi; EEQ31384; EEQ31384; MCYG_04203.
DR   GeneID; 9224536; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   HOGENOM; CLU_000288_103_1_1; -.
DR   OMA; KMCEQHI; -.
DR   OrthoDB; 617388at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..674
FT                   /note="Probable E3 ubiquitin ligase complex SCF subunit
FT                   sconB"
FT                   /id="PRO_0000397252"
FT   DOMAIN          212..258
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          336..375
FT                   /note="WD 1"
FT   REPEAT          377..415
FT                   /note="WD 2"
FT   REPEAT          416..453
FT                   /note="WD 3"
FT   REPEAT          455..496
FT                   /note="WD 4"
FT   REPEAT          557..600
FT                   /note="WD 5"
FT   REPEAT          603..640
FT                   /note="WD 6"
FT   REPEAT          643..674
FT                   /note="WD 7"
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..543
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  75511 MW;  B7F5558F0BF03F66 CRC64;
     MATDTPPQLA GPPTPAMETL DRDVVMSPRK RRRLSASAEP ELTEPESDGT SGGRGAAAEA
     PETAALEPKS LFNSTSTESS ITSSSTTTTT TSSSSSIAPF LAKHIRDQHA SRNRFAPADS
     SLPRRKADSK YCYRHRPDLK CRRQADEPTV DQMQRDLSTL SQNDQQSIAH FWSLFSAAPS
     KHRNLMLQGI VAQCCFPQLS FLSASVRDLI RIDFVTALPP EISFKILSYL DTASLCNAAQ
     VSRNWRHLAD DDVVWHRMCE QHIDRKCEKC GWGLPMLDRK RLKDTKRQVQ LRAAGKEAVT
     GRQQQQHRPW KAVYMDRFKV GTNWKYGRCT TTIFRGHTNG VMCLQFDDNI LATGSYDATI
     KIWDIETGKE IRTLRGHEST IRCLQFDDTK LISGSLDRTI KVWSWRSGEC ISTYTGHQGG
     VLCLHFDSTT LASGSKDNTI KIWNFQDKST QILRGHTDWV NAVKLDTASR TVFSASDDLT
     VRIWDLDTGK CIHTYAGHVG QVQQVLPLPR EFEFKHTSHC DDDRSDRLSG SESPDHRASH
     DSNHAPDLPT TSAPPTQPMS PLFEALFNED RPAPPRYMLT AALDSTLRLW EVHTGRCLRT
     FFGHIEGVWG LAADTLRLVS GAQDHMTKVW DPRTGTCERT FTGHRGPVTC VSLSDSRMAT
     GSEDCEVRMY SFKA