ID   SCOA_XANCB              Reviewed;         242 AA.
AC   B0RVK4; O34264;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A;
DE            EC=2.8.3.5;
DE   AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
DE            Short=OXCT A;
GN   Name=lpsI; Synonyms=wxcI; OrderedLocusNames=xcc-b100_3728;
OS   Xanthomonas campestris pv. campestris (strain B100).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=509169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=9385134; DOI=10.1007/s002030050520;
RA   Steinmann D., Koeplin R., Puehler A., Niehaus K.;
RT   "Xanthomonas campestris pv. campestris lpsI and lpsJ genes encoding
RT   putative proteins with sequence similarity to the alpha- and beta-subunits
RT   of 3-oxoacid CoA-transferases are involved in LPS biosynthesis.";
RL   Arch. Microbiol. 168:441-447(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11589581; DOI=10.1007/s004380100521;
RA   Vorhoelter F.-J., Niehaus K., Puehler A.;
RT   "Lipopolysaccharide biosynthesis in Xanthomonas campestris pv. campestris:
RT   a cluster of 15 genes is involved in the biosynthesis of the LPS O-antigen
RT   and the LPS core.";
RL   Mol. Genet. Genomics 266:79-95(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B100;
RX   PubMed=18304669; DOI=10.1016/j.jbiotec.2007.12.013;
RA   Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T.,
RA   Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K.,
RA   Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K.,
RA   Puehler A.;
RT   "The genome of Xanthomonas campestris pv. campestris B100 and its use for
RT   the reconstruction of metabolic pathways involved in xanthan
RT   biosynthesis.";
RL   J. Biotechnol. 134:33-45(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBUNIT: Heterodimer of a subunit A and a subunit B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC       {ECO:0000305}.
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DR   EMBL; AF204145; AAK53462.1; -; Genomic_DNA.
DR   EMBL; AM920689; CAP53095.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0RVK4; -.
DR   SMR; B0RVK4; -.
DR   KEGG; xca:xcc-b100_3728; -.
DR   HOGENOM; CLU_019942_2_0_6; -.
DR   OMA; QLAPECI; -.
DR   UniPathway; UPA00030; -.
DR   Proteomes; UP000001188; Chromosome.
DR   GO; GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004163; CoA_transf_BS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR   PROSITE; PS01273; COA_TRANSF_1; 1.
PE   3: Inferred from homology;
KW   Lipopolysaccharide biosynthesis; Transferase.
FT   CHAIN           1..242
FT                   /note="Succinyl-CoA:3-ketoacid coenzyme A transferase
FT                   subunit A"
FT                   /id="PRO_0000333181"
FT   BINDING         33..39
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        101..109
FT                   /note="ELELEFNPQ -> RTRAGIQSA (in Ref. 1; no nucleotide
FT                   entry and 2; AAK53462)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   242 AA;  25796 MW;  FA0FF5C1DB0CB84A CRC64;
     MNQVARGAGA KRYADAKAAL AGVVADGQTL AVGGFGLCGI PEALITALRD SAVSGLTVIS
     NNAGVDGFGL GQLLATRQIR KMISSYVGEN KEFERQYLAG ELELEFNPQG TLAERLRAGG
     AGIPAFYTAT GYGTIVADGK ETREFDGKHY VLETALQADV ALIKAWRADT AGNLVFRKTA
     RNFNPACAMA GRICIAEVEE IVELGAIDPD QVHLPGIYVD RLVLNATPEK RIEQRTVRQG
     DK