ID   SCOA_MYCTU              Reviewed;         248 AA.
AC   P9WPW5; L0TCJ8; O06167; P63648;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A;
DE            EC=2.8.3.5;
DE   AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
DE            Short=OXCT A;
GN   Name=scoA; OrderedLocusNames=Rv2504c; ORFNames=MTCY07A7.10c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC   -!- SUBUNIT: Heterodimer of a subunit A and a subunit B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45298.1; -; Genomic_DNA.
DR   PIR; H70550; H70550.
DR   RefSeq; NP_217020.1; NC_000962.3.
DR   RefSeq; WP_003412786.1; NZ_NVQJ01000063.1.
DR   AlphaFoldDB; P9WPW5; -.
DR   SMR; P9WPW5; -.
DR   STRING; 83332.Rv2504c; -.
DR   PaxDb; P9WPW5; -.
DR   DNASU; 888503; -.
DR   GeneID; 45426498; -.
DR   GeneID; 888503; -.
DR   KEGG; mtu:Rv2504c; -.
DR   TubercuList; Rv2504c; -.
DR   eggNOG; COG1788; Bacteria.
DR   OMA; FVKAWKG; -.
DR   PhylomeDB; P9WPW5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IBA:GO_Central.
DR   GO; GO:0008410; F:CoA-transferase activity; IBA:GO_Central.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004163; CoA_transf_BS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR   PROSITE; PS01273; COA_TRANSF_1; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Transferase.
FT   CHAIN           1..248
FT                   /note="Probable succinyl-CoA:3-ketoacid coenzyme A
FT                   transferase subunit A"
FT                   /id="PRO_0000157911"
FT   BINDING         24..30
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  26276 MW;  81340193CC48EBD1 CRC64;
     MDKVVATAAE AVADIANGSS LAVGGFGLCG IPEALIAALV DSGVTDLETV SNNCGIDGVG
     LGLLLQHKRI RRTVSSYVGE NKEFARQFLA GELEVELTPQ GTLAERLRAG GMGIPAFYTP
     AGVGTQVADG GLPWRYDASG GVAVVSPAKE TREFDGVTYV LERGIRTDFA LVHAWQGDRH
     GNLMYRHAAA NFNPECASAG RITIAEVEHL VEPGEIDPAT VHTPGVFVHR VVHVPNPAKK
     IERETVRQ