SCOA_BACSU
ID SCOA_BACSU Reviewed; 238 AA.
AC P42315;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A;
DE EC=2.8.3.5;
DE AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
DE Short=OXCT A;
GN Name=scoA; Synonyms=yxjD; OrderedLocusNames=BSU38990; ORFNames=N15K;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=8969509; DOI=10.1099/13500872-142-11-3113;
RA Yoshida K., Shindo K., Sano H., Seki S., Fujimura M., Yanai N., Miwa Y.,
RA Fujita Y.;
RT "Sequencing of a 65 kb region of the Bacillus subtilis genome containing
RT the lic and cel loci, and creation of a 177 kb contig covering the gnt-
RT sacXY region.";
RL Microbiology 142:3113-3123(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC -!- SUBUNIT: Heterodimer of a subunit A and a subunit B. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC {ECO:0000305}.
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DR EMBL; D83026; BAA11705.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15925.1; -; Genomic_DNA.
DR PIR; B70079; B70079.
DR RefSeq; NP_391778.1; NC_000964.3.
DR RefSeq; WP_003244373.1; NZ_JNCM01000034.1.
DR PDB; 3CDK; X-ray; 2.59 A; A/C=1-238.
DR PDBsum; 3CDK; -.
DR AlphaFoldDB; P42315; -.
DR SMR; P42315; -.
DR STRING; 224308.BSU38990; -.
DR PaxDb; P42315; -.
DR PRIDE; P42315; -.
DR EnsemblBacteria; CAB15925; CAB15925; BSU_38990.
DR GeneID; 937468; -.
DR KEGG; bsu:BSU38990; -.
DR PATRIC; fig|224308.179.peg.4219; -.
DR eggNOG; COG1788; Bacteria.
DR InParanoid; P42315; -.
DR OMA; HDGATVM; -.
DR PhylomeDB; P42315; -.
DR BioCyc; BSUB:BSU38990-MON; -.
DR EvolutionaryTrace; P42315; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008775; F:acetate CoA-transferase activity; IBA:GO_Central.
DR GO; GO:0008410; F:CoA-transferase activity; IBA:GO_Central.
DR InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR InterPro; IPR004165; CoA_trans_fam_I.
DR InterPro; IPR004163; CoA_transf_BS.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR13707; PTHR13707; 1.
DR Pfam; PF01144; CoA_trans; 1.
DR SMART; SM00882; CoA_trans; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR PROSITE; PS01273; COA_TRANSF_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Transferase.
FT CHAIN 1..238
FT /note="Probable succinyl-CoA:3-ketoacid coenzyme A
FT transferase subunit A"
FT /id="PRO_0000157908"
FT BINDING 24..30
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000255"
FT HELIX 8..12
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 20..23
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 33..42
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 46..53
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 62..66
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 70..77
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 82..88
FT /evidence="ECO:0007829|PDB:3CDK"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 92..97
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 100..112
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 116..120
FT /evidence="ECO:0007829|PDB:3CDK"
FT TURN 121..124
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 126..128
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 133..136
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 139..145
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 149..160
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 169..171
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 175..181
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 182..193
FT /evidence="ECO:0007829|PDB:3CDK"
FT TURN 200..202
FT /evidence="ECO:0007829|PDB:3CDK"
FT HELIX 207..209
FT /evidence="ECO:0007829|PDB:3CDK"
FT STRAND 211..215
FT /evidence="ECO:0007829|PDB:3CDK"
SQ SEQUENCE 238 AA; 25399 MW; E88552A437098CE0 CRC64;
MGKVLSSSKE AAKLIHDGDT LIAGGFGLCG IPEQLILSIR DQGVKDLTVV SNNCGVDDWG
LGLLLANKQI KKMIASYVGE NKIFERQFLS GELEVELVPQ GTLAERIRAG GAGIPGFYTA
TGVGTSIAEG KEHKTFGGRT YVLERGITGD VAIVKAWKAD TMGNLIFRKT ARNFNPIAAM
AGKITIAEAE EIVEAGELDP DHIHTPGIYV QHVVLGASQE KRIEKRTVQQ ASGKGEAK
