ID   SCFD1_DICDI             Reviewed;         673 AA.
AC   Q54IJ1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Sec1 family domain-containing protein 1 homolog;
GN   Name=scfd1; ORFNames=DDB_G0288719;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in vesicular transport between the endoplasmic
CC       reticulum and the Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000120; EAL63091.2; -; Genomic_DNA.
DR   RefSeq; XP_636595.2; XM_631503.2.
DR   AlphaFoldDB; Q54IJ1; -.
DR   SMR; Q54IJ1; -.
DR   STRING; 44689.DDB0234142; -.
DR   PaxDb; Q54IJ1; -.
DR   PRIDE; Q54IJ1; -.
DR   EnsemblProtists; EAL63091; EAL63091; DDB_G0288719.
DR   GeneID; 8626770; -.
DR   KEGG; ddi:DDB_G0288719; -.
DR   dictyBase; DDB_G0288719; scfd1.
DR   eggNOG; KOG1301; Eukaryota.
DR   HOGENOM; CLU_016216_3_1_1; -.
DR   InParanoid; Q54IJ1; -.
DR   OMA; DRQLDNF; -.
DR   PhylomeDB; Q54IJ1; -.
DR   Reactome; R-DDI-204005; COPII-mediated vesicle transport.
DR   PRO; PR:Q54IJ1; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..673
FT                   /note="Sec1 family domain-containing protein 1 homolog"
FT                   /id="PRO_0000328236"
SQ   SEQUENCE   673 AA;  75522 MW;  9419112015FB0B54 CRC64;
     MNQNSSLSSS GMMGSGGFGF DQFSNNFSIK TKQIESINKM LSLKSESSSS NNNNNNNKAI
     SGWQEVWKVL IFDTHCSNII APILTKGALR NQGVTLYLPL HSDRQPIQDV PAIYFVLPTS
     DNIKRIAEDC KNKLYDNIYL NFASKLSNQL MEELATLTIQ SDSVSMISKV YDQFLNFISL
     ENDLFVLNNP RDSYLSFNDT RIKDTQAQEN IDMVVDSLFS VLVTLGVVPI IRAPKNSAAE
     MIALALEKRI STTLQSSGGS NVFSNMNEMG SQLSSFYRPV LILLDRNVDL SVCLHHPWTY
     QALVHDVLNM SLNQVRIDVT QNGQTSKKSY GLDSSSDSFW SSNTGAAFSS VAGEIKSQIN
     EYYQQMEKLQ QITDIKLDDS DDFDNNNKKS NENKTKGLGN LVQEMDEKKR LIDIHTNLAT
     DLTKNIRDRQ IDCFFAMEES IITRSLTDKK ELHSLITSPI VGETGGRGTL EDKIRLLIIY
     FLSTKNVPQS EMDQYEDALT KMGADLSTLD FFKKTKAFNE SLTAIANVNQ SSTQSSNTAS
     GKIGGFMQMM TSVTGYQGVE SFTNFFQQGV RALLPKSKDL FVTRIVESIM DLKNTLDADY
     LYLDPKIQNK SNVPKRTTPF KEAIVFTVGG GNYVEYQNLQ DFSKKHNKKI IYGSNELLTS
     KEFLNQIKNL NKN