ID   SAMHT_CHLTR             Reviewed;         327 AA.
AC   O84584;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=S-adenosylmethionine/S-adenosylhomocysteine transporter;
DE            Short=SAM/SAH transporter;
DE            Short=SAMHT;
GN   OrderedLocusNames=CT_580;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Transports S-adenosylmethionine (SAM) and S-
CC       adenosylhomocysteine (SAH). Allows bacteria to acquire SAM from the
CC       eukaryotic host cell and to likely remove the toxic by-product SAH (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC       {ECO:0000305}.
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DR   EMBL; AE001273; AAC68182.1; -; Genomic_DNA.
DR   PIR; F71497; F71497.
DR   RefSeq; NP_220095.1; NC_000117.1.
DR   RefSeq; WP_010725258.1; NC_000117.1.
DR   AlphaFoldDB; O84584; -.
DR   SMR; O84584; -.
DR   STRING; 813.O172_03180; -.
DR   EnsemblBacteria; AAC68182; AAC68182; CT_580.
DR   GeneID; 884358; -.
DR   KEGG; ctr:CT_580; -.
DR   PATRIC; fig|272561.5.peg.632; -.
DR   HOGENOM; CLU_080359_0_0_0; -.
DR   InParanoid; O84584; -.
DR   OMA; AYGLFFY; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..327
FT                   /note="S-adenosylmethionine/S-adenosylhomocysteine
FT                   transporter"
FT                   /id="PRO_0000414248"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..157
FT                   /note="EamA 1"
FT   DOMAIN          189..313
FT                   /note="EamA 2"
SQ   SEQUENCE   327 AA;  35942 MW;  FA5B8AA79A95DB8F CRC64;
     MVAVKALLFA CTLQTCVFKP CCDMAIFLIF LNAFIWSSSF ALSKSAMEAA APLFVTGSRM
     VLAGVVLFGL LLCKRESLRL PRPAIMPIVL LSVIGFYLTN VLEFIGLQGL SSSTACFIYG
     FSPFTAAFCS YVQLREVVTW KKLGGLSLGL VSYLVYLLFG GSEDVAEWGW QLGLPELLLI
     AATCLSSYGW TLLRKLGRRC ESLSMTAINA YAMVIAGVLS LIHSAVTEVW NPVPVENPLL
     FLQAIGALVI FSNLICYNLF AKLLRSFSST FLSFCNLVMP LFASFFGWLL LGESFPPGLL
     FAVGFMVLGC RLIYHEEFRQ GYVLTSE