SALA_DROME
ID SALA_DROME Reviewed; 142 AA.
AC P21750; Q9VKH1;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein spalt-accessory;
DE AltName: Full=Protein spalt-adjacent;
DE Flags: Precursor;
GN Name=sala; Synonyms=sal; ORFNames=CG4922;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16453821; DOI=10.1002/j.1460-2075.1988.tb02800.x;
RA Frei E., Schuh R., Baumgartner S., Burri M., Noll M., Juergens G.,
RA Seifert E., Nauber U., Jaeckle H.;
RT "Molecular characterization of spalt, a homeotic gene required for head and
RT tail development in the Drosophila embryo.";
RL EMBO J. 7:197-204(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=2568636; DOI=10.1073/pnas.86.14.5483;
RA Reuter D., Schuh R., Jaeckle H.;
RT "The homeotic gene spalt (sal) evolved during Drosophila speciation.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:5483-5486(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8601339; DOI=10.1007/bf00352268;
RA Reuter D., Kuhnlein R.P., Frommer G., Barrio R., Kafatos F.C., Jackle H.,
RA Schuh R.;
RT "Regulation, function and potential origin of the Drosophila gene spalt
RT adjacent, which encodes a secreted protein expressed in the early embryo.";
RL Chromosoma 104:445-454(1996).
CC -!- FUNCTION: Likely to be involved in the establishment of the head.
CC {ECO:0000269|PubMed:2568636, ECO:0000269|PubMed:8601339}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8601339}.
CC -!- DEVELOPMENTAL STAGE: Expressed in temporally and spatially restricted
CC patterns during embryogenesis in the anterior, ventral and terminal
CC regions of the embryo. {ECO:0000269|PubMed:8601339}.
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DR EMBL; X57474; CAA40712.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF53098.1; -; Genomic_DNA.
DR EMBL; AY075486; AAL68296.1; -; mRNA.
DR PIR; S00262; S00262.
DR RefSeq; NP_001245985.1; NM_001259056.1.
DR RefSeq; NP_523549.1; NM_078825.4.
DR AlphaFoldDB; P21750; -.
DR BioGRID; 60627; 16.
DR IntAct; P21750; 3.
DR STRING; 7227.FBpp0300458; -.
DR PaxDb; P21750; -.
DR DNASU; 34570; -.
DR EnsemblMetazoa; FBtr0080237; FBpp0079824; FBgn0003313.
DR EnsemblMetazoa; FBtr0308136; FBpp0300458; FBgn0003313.
DR GeneID; 34570; -.
DR KEGG; dme:Dmel_CG4922; -.
DR CTD; 34570; -.
DR FlyBase; FBgn0003313; sala.
DR VEuPathDB; VectorBase:FBgn0003313; -.
DR HOGENOM; CLU_1837223_0_0_1; -.
DR OMA; HEYPEHH; -.
DR PhylomeDB; P21750; -.
DR BioGRID-ORCS; 34570; 0 hits in 1 CRISPR screen.
DR ChiTaRS; sls; fly.
DR GenomeRNAi; 34570; -.
DR PRO; PR:P21750; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0003313; Expressed in anlage and 57 other tissues.
DR Genevisible; P21750; DM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007369; P:gastrulation; IEP:FlyBase.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..142
FT /note="Protein spalt-accessory"
FT /id="PRO_0000022267"
FT REGION 75..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..142
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 15
FT /note="N -> I (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 59
FT /note="G -> S (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="T -> A (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 14555 MW; 7DC7C6D210309A87 CRC64;
MKLLIALFAL VTAVNAQNGF GQVGQGGYGG QGGFGGFGGI GGQAGFGGQI GFTGQGGVGG
QVGIGQGGVH PGQGGFAGQG SPNQYQPGYG SPVGSGHFHG TNPVESGHFH ENPHEYPEHH
GDHHREHHEH HGHHEHHGHH RH
