ID   S6A17_BOVIN             Reviewed;         225 AA.
AC   Q28001;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Sodium-dependent neutral amino acid transporter SLC6A17;
DE   AltName: Full=Sodium-dependent neurotransmitter transporter NTT4;
DE   AltName: Full=Solute carrier family 6 member 17;
DE   Flags: Fragment;
GN   Name=SLC6A17; Synonyms=NTT4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Jones E.M.C.;
RT   "Sodium- and chloride-dependent neurotransmitter transporters in bovine
RT   retina: identification and localization by in situ hybridization
RT   histochemistry.";
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a sodium-dependent vesicular transporter
CC       selective for proline, glycine, leucine and alanine. In contrast to
CC       other members of this neurotransmitter transporter family, does not
CC       appear to be chloride-dependent (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250|UniProtKB:P31662}; Multi-pass membrane
CC       protein {ECO:0000250|UniProtKB:P31662}. Postsynapse
CC       {ECO:0000250|UniProtKB:Q8BJI1}. Presynapse
CC       {ECO:0000250|UniProtKB:Q8BJI1}. Note=Localizes at synaptic junctions
CC       - at both pre- and post-synaptic sites - particularly in excitatory
CC       glutamatergic terminals. {ECO:0000250|UniProtKB:Q8BJI1}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. SLC6A17 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U19593; AAA61578.1; -; mRNA.
DR   AlphaFoldDB; Q28001; -.
DR   SMR; Q28001; -.
DR   STRING; 9913.ENSBTAP00000002571; -.
DR   PaxDb; Q28001; -.
DR   PRIDE; Q28001; -.
DR   eggNOG; KOG3659; Eukaryota.
DR   InParanoid; Q28001; -.
DR   OrthoDB; 250396at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031224; C:intrinsic component of membrane; IBA:GO_Central.
DR   GO; GO:0098794; C:postsynapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0032328; P:alanine transport; ISS:UniProtKB.
DR   GO; GO:0015816; P:glycine transport; ISS:UniProtKB.
DR   GO; GO:0015820; P:leucine transport; ISS:UniProtKB.
DR   GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR   GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR   GO; GO:0015824; P:proline transport; ISS:UniProtKB.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; PTHR11616; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SSF161070; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasmic vesicle; Glycoprotein; Membrane;
KW   Neurotransmitter transport; Reference proteome; Symport; Synapse;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           <1..>225
FT                   /note="Sodium-dependent neutral amino acid transporter
FT                   SLC6A17"
FT                   /id="PRO_0000214802"
FT   TRANSMEM        <1..8
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..35
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..143
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..188
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..>225
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         225
SQ   SEQUENCE   225 AA;  25374 MW;  3FA15D33F76D15C3 CRC64;
     NVWRFPYLCQ KNGGGAYLVP YLVLLIIIGI PLFFLELAVG QRIRRGSIGV WHYVCPRLGG
     IGFSSCIVCL FVGLYYNVII GWSIFYFFKS FQYPLPWSEC PVSRNGTVAV VEAECEKSSA
     TTYFWYREAL DISNSISESG GLNWKMTLCL LVAWRIVGMA VVKGIQSSGK VMYFSSLFPY
     VVLACFLVRG LLLRGAIDGI LHMFTPKLDK MLDPQVWRDA ATQIF