S47A1_XENTR
ID S47A1_XENTR Reviewed; 574 AA.
AC A4IIS8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Multidrug and toxin extrusion protein 1;
DE Short=MATE-1;
DE AltName: Full=Solute carrier family 47 member 1;
GN Name=slc47a1; Synonyms=mate1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Solute transporter for tetraethylammonium (TEA), cimetidine,
CC metformin, guanidine, N-methylnicotinamide (NMN) and also the
CC zwitterionic cephalosporin cephalexin. Responsible for the secretion of
CC cationic drugs across the brush border membranes (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; BC136138; AAI36139.1; -; mRNA.
DR RefSeq; NP_001096440.1; NM_001102970.1.
DR AlphaFoldDB; A4IIS8; -.
DR SMR; A4IIS8; -.
DR GeneID; 100125051; -.
DR KEGG; xtr:100125051; -.
DR CTD; 146802; -.
DR Xenbase; XB-GENE-5793831; slc47a2.
DR eggNOG; KOG1347; Eukaryota.
DR InParanoid; A4IIS8; -.
DR OrthoDB; 743037at2759; -.
DR Reactome; R-XTR-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..574
FT /note="Multidrug and toxin extrusion protein 1"
FT /id="PRO_0000312851"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..350
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..384
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 452..453
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 473..549
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 571..574
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 500..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 61887 MW; CDC2BA5D2D406B15 CRC64;
MEGQAAETNH RAETVVRAEL CLSAEQGPET TAYSQKRCLF LPMEVWQEAQ QLLALAAPAF
LSQLMIFLIS IVSSIFCGHL GKVELDAVSL AITIINITGV AVGTGLAGAC DTLISQTFGG
SNLKLVGIIL QRGILILLLF CFPCWALLIN TESILLLFRQ DPEVSKLTQI YVLIFLPALP
AAFLYQLLAK YLQNQGIIYP QVLTGFIANI FNALFNYILL YVLGLGVMGS ACANTVSQFI
QMILLFLYIV WRRLYADTWG GWSQACFEEW GAFIRLAVAS MLMLCIEWWA FEISMFLAGV
LGMVDLAAQA IIYQVAIVVY LIPLGLCIAG SIRVGHGLGA GNTEQAKRSA LVVLCMTELC
ALLSGILLAT LKDVVAYIFT SDPNIVALVS YVLPVYSACL LFDACVAACG GILRGSGKLK
VGAISHTVGY YVIGLPLGIS LMFAAKLGII GFWFGILACG IAQSIFLIIF VFKIDWKRAS
EEAQTRASER VEIPQKIDNK PSVYQEGCPT EQGDVDPGNV ESIEFSQSST SSEGTSPTPA
GAAQHTRTLI LTRGLALGCA VGTLIIGIVI RLSV
