S40A1_ARATH
ID S40A1_ARATH Reviewed; 524 AA.
AC O80905;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Solute carrier family 40 member 1;
DE AltName: Full=Ferroportin-1;
DE AltName: Full=Iron-regulated transporter 1;
DE Short=AtIREG1;
GN Name=IREG1; Synonyms=FPN1; OrderedLocusNames=At2g38460; ORFNames=T19C21.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000305}.
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DR EMBL; AC004683; AAC28758.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09539.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61309.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61311.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61312.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61313.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61315.1; -; Genomic_DNA.
DR PIR; T02499; T02499.
DR RefSeq; NP_001323535.1; NM_001336703.1.
DR RefSeq; NP_001323537.1; NM_001336700.1.
DR RefSeq; NP_001323538.1; NM_001336704.1.
DR RefSeq; NP_001323539.1; NM_001336701.1.
DR RefSeq; NP_001323541.1; NM_001336705.1.
DR RefSeq; NP_181380.1; NM_129402.6.
DR AlphaFoldDB; O80905; -.
DR SMR; O80905; -.
DR BioGRID; 3769; 4.
DR STRING; 3702.AT2G38460.1; -.
DR TCDB; 2.A.100.1.3; the ferroportin (fpn) family.
DR PaxDb; O80905; -.
DR PRIDE; O80905; -.
DR EnsemblPlants; AT2G38460.1; AT2G38460.1; AT2G38460.
DR EnsemblPlants; AT2G38460.3; AT2G38460.3; AT2G38460.
DR EnsemblPlants; AT2G38460.4; AT2G38460.4; AT2G38460.
DR EnsemblPlants; AT2G38460.6; AT2G38460.6; AT2G38460.
DR EnsemblPlants; AT2G38460.7; AT2G38460.7; AT2G38460.
DR EnsemblPlants; AT2G38460.8; AT2G38460.8; AT2G38460.
DR GeneID; 818427; -.
DR Gramene; AT2G38460.1; AT2G38460.1; AT2G38460.
DR Gramene; AT2G38460.3; AT2G38460.3; AT2G38460.
DR Gramene; AT2G38460.4; AT2G38460.4; AT2G38460.
DR Gramene; AT2G38460.6; AT2G38460.6; AT2G38460.
DR Gramene; AT2G38460.7; AT2G38460.7; AT2G38460.
DR Gramene; AT2G38460.8; AT2G38460.8; AT2G38460.
DR KEGG; ath:AT2G38460; -.
DR Araport; AT2G38460; -.
DR TAIR; locus:2057222; AT2G38460.
DR eggNOG; KOG2601; Eukaryota.
DR HOGENOM; CLU_020370_1_0_1; -.
DR InParanoid; O80905; -.
DR OMA; NVHELEH; -.
DR OrthoDB; 334057at2759; -.
DR PhylomeDB; O80905; -.
DR PRO; PR:O80905; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80905; baseline and differential.
DR Genevisible; O80905; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006824; P:cobalt ion transport; IMP:TAIR.
DR GO; GO:0006826; P:iron ion transport; IBA:GO_Central.
DR CDD; cd17480; MFS_SLC40A1_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; PTHR11660; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..524
FT /note="Solute carrier family 40 member 1"
FT /id="PRO_0000415898"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 58204 MW; 781C6C0A697FADB1 CRC64;
MENETELRVV HQEEQQREEG EDESQPQNPP PALRRRFVIY LYVGYFLARW SARTWEFSVA
LYMIHLWPNS LLLAAIYGAI ESGSTAIFGP IVGQWVEGMD YVKVLRLWLL FQNLSYTIAG
GAVIKLLLVS DLKSRNLPVF AILIVLTNLA GAIGVLSTLA GTILIERDWA VVMSEGHPPA
VLTKMNSVIR GIDLSSKLLS PVITGLIISF VSLKASAITF AAWATITAWV EYWLFISVYS
GVPAITRSNE RRILRSRTKQ VEGRDAPVSV SIVPGTEEGY TGNPPSRTGI LVILDRMSKS
SFVGAWRIYF NQEVVLPGVS LALLFFTVLS FGTLMTATLQ WEGIPTYIIG IGRGISATVG
LAATLVYPLM QSRLSTLRTG LWSFWSQWSC LLVCVGSIWV KKDKIASYML MAGVAASRLG
LWMFDLAVIQ QMQDLVSESD RCVVGGVQNS LQSALDLMAY LLGIIVSNPK DFWILTLISF
STVSLAGMLY TIHLYRIRNH IFHLEKIPLL NKCIFKLLPS RGNV
