S35F5_MOUSE
ID S35F5_MOUSE Reviewed; 524 AA.
AC Q8R314; Q9DBK9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Solute carrier family 35 member F5;
GN Name=Slc35f5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Amnion, Liver, Placenta, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative solute transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC {ECO:0000305}.
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DR EMBL; AK004892; BAB23648.1; -; mRNA.
DR EMBL; AK145848; BAE26695.1; -; mRNA.
DR EMBL; AK169012; BAE40809.1; -; mRNA.
DR EMBL; AK171951; BAE42744.1; -; mRNA.
DR EMBL; BC026858; AAH26858.1; -; mRNA.
DR CCDS; CCDS35694.1; -.
DR RefSeq; NP_083063.2; NM_028787.4.
DR AlphaFoldDB; Q8R314; -.
DR STRING; 10090.ENSMUSP00000027580; -.
DR iPTMnet; Q8R314; -.
DR PhosphoSitePlus; Q8R314; -.
DR PaxDb; Q8R314; -.
DR PRIDE; Q8R314; -.
DR ProteomicsDB; 256563; -.
DR Antibodypedia; 33350; 88 antibodies from 21 providers.
DR DNASU; 74150; -.
DR Ensembl; ENSMUST00000027580; ENSMUSP00000027580; ENSMUSG00000026342.
DR GeneID; 74150; -.
DR KEGG; mmu:74150; -.
DR UCSC; uc007ckg.1; mouse.
DR CTD; 80255; -.
DR MGI; MGI:1921400; Slc35f5.
DR VEuPathDB; HostDB:ENSMUSG00000026342; -.
DR eggNOG; KOG2765; Eukaryota.
DR GeneTree; ENSGT00390000005949; -.
DR HOGENOM; CLU_026578_2_1_1; -.
DR InParanoid; Q8R314; -.
DR OMA; KVCRCHK; -.
DR OrthoDB; 1084257at2759; -.
DR PhylomeDB; Q8R314; -.
DR TreeFam; TF314261; -.
DR BioGRID-ORCS; 74150; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Slc35f5; mouse.
DR PRO; PR:Q8R314; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8R314; protein.
DR Bgee; ENSMUSG00000026342; Expressed in interventricular septum and 248 other tissues.
DR ExpressionAtlas; Q8R314; baseline and differential.
DR Genevisible; Q8R314; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..524
FT /note="Solute carrier family 35 member F5"
FT /id="PRO_0000311958"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 253..317
FT /note="EamA"
FT MOD_RES 207
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WV83"
FT CONFLICT 103
FT /note="S -> N (in Ref. 1; BAB23648)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 524 AA; 58613 MW; C0D2F32E6EC26927 CRC64;
MVPPRLHRGA GRPGGLSSLP PFGLGSARFA GIAFEDLREA LATRLQMVYV FIMNRVNSQS
SGFSQRRRMA LGIVILLLVD VIWVASSELT SYVFTQYNKP FFSTFAKTSM FVLYLLGFII
WKPWRQQCTR GFRGKPAAFF ADAEGYFAAC TTDTSMSSSL SEPLYVPVKF HDLPSEKLES
TNIGTEKTPK KSRVRFSNIM EIRQLPSSHA LEAKLSRMSY PTVKDQESIL KTVGKLTATQ
VAKISFFFCF VWFLANLSYQ EALSDTQVAI VNILSSTSGL FTLILAAVFP SNSGDRFTLS
KLLAVILSIG GVVLVNLSGS EKSAGRDTIG SIWSLAGAMF YAVYIVMIKR KVDREDKLDI
PMFFGFVGLF NLLLLWPGFF LLHYTGFEDF EFPNKVVLLC IIINGLIGTV LSEFLWLWGC
FLTSSLIGTL ALSLTIPLSI IADMCMQKVQ FSWLFFAGAI PVFFSFFIVT LLCHYNNWDP
VMVGVRRVFA FICRKHRIQR VPEDSEQCES LISMHSVSQE DGAT
