S22AB_HUMAN
ID S22AB_HUMAN Reviewed; 550 AA.
AC Q9NSA0; A8K426; Q53GR2; Q6ZP72; Q8NBU4;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Solute carrier family 22 member 11;
DE AltName: Full=Organic anion transporter 4;
GN Name=SLC22A11; Synonyms=OAT4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=10660625; DOI=10.1074/jbc.275.6.4507;
RA Cha S.H., Sekine T., Kusuhara H., Yu E., Kim J.Y., Kim D.K., Sugiyama Y.,
RA Kanai Y., Endou H.;
RT "Molecular cloning and characterization of multispecific organic anion
RT transporter 4 expressed in the placenta.";
RL J. Biol. Chem. 275:4507-4512(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP MUTAGENESIS OF HIS-47; HIS-52; HIS-83; HIS-305 AND HIS-469, FUNCTION, AND
RP SUBCELLULAR LOCATION.
RX PubMed=15291761; DOI=10.1042/bj20040751;
RA Zhou F., Pan Z., Ma J., You G.;
RT "Mutational analysis of histidine residues in human organic anion
RT transporter 4 (hOAT4).";
RL Biochem. J. 384:87-92(2004).
RN [8]
RP FUNCTION, AND MUTAGENESIS OF GLY-241 AND GLY-400.
RX PubMed=15102942; DOI=10.1124/mol.65.5.1141;
RA Zhou F., Tanaka K., Pan Z., Ma J., You G.;
RT "The role of glycine residues in the function of human organic anion
RT transporter 4.";
RL Mol. Pharmacol. 65:1141-1147(2004).
RN [9]
RP MUTAGENESIS OF ASN-39; ASN-56; ASN-63 AND ASN-99, SUBCELLULAR LOCATION, AND
RP GLYCOSYLATION.
RX PubMed=15576633; DOI=10.1124/mol.104.007583;
RA Zhou F., Xu W., Hong M., Pan Z., Sinko P.J., Ma J., You G.;
RT "The role of N-linked glycosylation in protein folding, membrane targeting,
RT and substrate binding of human organic anion transporter hOAT4.";
RL Mol. Pharmacol. 67:868-876(2005).
CC -!- FUNCTION: Mediates saturable uptake of estrone sulfate,
CC dehydroepiandrosterone sulfate and related compounds.
CC {ECO:0000269|PubMed:10660625, ECO:0000269|PubMed:15102942,
CC ECO:0000269|PubMed:15291761}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15291761,
CC ECO:0000269|PubMed:15576633}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NSA0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NSA0-2; Sequence=VSP_018319;
CC -!- TISSUE SPECIFICITY: Detected in placenta and kidney.
CC {ECO:0000269|PubMed:10660625}.
CC -!- PTM: N-glycosylated. Contains several complex-type N-glycans.
CC {ECO:0000269|PubMed:15576633}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC11483.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB026116; BAA95316.1; -; mRNA.
DR EMBL; AK075224; BAC11483.1; ALT_INIT; mRNA.
DR EMBL; AK129930; BAC85252.1; -; mRNA.
DR EMBL; AK222869; BAD96589.1; -; mRNA.
DR EMBL; AK290791; BAF83480.1; -; mRNA.
DR EMBL; AC044790; AAK68155.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW74269.1; -; Genomic_DNA.
DR EMBL; BC034384; AAH34384.1; -; mRNA.
DR CCDS; CCDS76425.1; -. [Q9NSA0-2]
DR CCDS; CCDS8074.1; -. [Q9NSA0-1]
DR RefSeq; NP_001294914.1; NM_001307985.1. [Q9NSA0-2]
DR RefSeq; NP_060954.1; NM_018484.3. [Q9NSA0-1]
DR AlphaFoldDB; Q9NSA0; -.
DR SMR; Q9NSA0; -.
DR BioGRID; 120967; 4.
DR IntAct; Q9NSA0; 1.
DR STRING; 9606.ENSP00000301891; -.
DR BindingDB; Q9NSA0; -.
DR ChEMBL; CHEMBL2073677; -.
DR DrugBank; DB00345; Aminohippuric acid.
DR DrugBank; DB00168; Aspartame.
DR DrugBank; DB01053; Benzylpenicillin.
DR DrugBank; DB00887; Bumetanide.
DR DrugBank; DB04519; Caprylic acid.
DR DrugBank; DB00456; Cefalotin.
DR DrugBank; DB01326; Cefamandole.
DR DrugBank; DB01327; Cefazolin.
DR DrugBank; DB01329; Cefoperazone.
DR DrugBank; DB00493; Cefotaxime.
DR DrugBank; DB01212; Ceftriaxone.
DR DrugBank; DB00501; Cimetidine.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB04133; Degraded Cephaloridine.
DR DrugBank; DB09213; Dexibuprofen.
DR DrugBank; DB00586; Diclofenac.
DR DrugBank; DB01160; Dinoprost tromethamine.
DR DrugBank; DB00917; Dinoprostone.
DR DrugBank; DB08846; Ellagic acid.
DR DrugBank; DB00783; Estradiol.
DR DrugBank; DB13952; Estradiol acetate.
DR DrugBank; DB13953; Estradiol benzoate.
DR DrugBank; DB13954; Estradiol cypionate.
DR DrugBank; DB13955; Estradiol dienanthate.
DR DrugBank; DB13956; Estradiol valerate.
DR DrugBank; DB00695; Furosemide.
DR DrugBank; DB03553; Glutaric Acid.
DR DrugBank; DB00999; Hydrochlorothiazide.
DR DrugBank; DB01050; Ibuprofen.
DR DrugBank; DB00328; Indomethacin.
DR DrugBank; DB01009; Ketoprofen.
DR DrugBank; DB11560; Lesinurad.
DR DrugBank; DB06282; Levocetirizine.
DR DrugBank; DB00563; Methotrexate.
DR DrugBank; DB01051; Novobiocin.
DR DrugBank; DB00595; Oxytetracycline.
DR DrugBank; DB00812; Phenylbutazone.
DR DrugBank; DB00554; Piroxicam.
DR DrugBank; DB00175; Pravastatin.
DR DrugBank; DB01032; Probenecid.
DR DrugBank; DB12377; Relebactam.
DR DrugBank; DB00936; Salicylic acid.
DR DrugBank; DB00759; Tetracycline.
DR DrugBank; DB00495; Zidovudine.
DR DrugCentral; Q9NSA0; -.
DR GuidetoPHARMACOLOGY; 1030; -.
DR TCDB; 2.A.1.19.10; the major facilitator superfamily (mfs).
DR GlyGen; Q9NSA0; 3 sites.
DR iPTMnet; Q9NSA0; -.
DR PhosphoSitePlus; Q9NSA0; -.
DR BioMuta; SLC22A11; -.
DR DMDM; 74734337; -.
DR MassIVE; Q9NSA0; -.
DR PaxDb; Q9NSA0; -.
DR PeptideAtlas; Q9NSA0; -.
DR PRIDE; Q9NSA0; -.
DR ProteomicsDB; 82518; -. [Q9NSA0-1]
DR ProteomicsDB; 82519; -. [Q9NSA0-2]
DR Antibodypedia; 15467; 104 antibodies from 20 providers.
DR DNASU; 55867; -.
DR Ensembl; ENST00000301891.9; ENSP00000301891.4; ENSG00000168065.16. [Q9NSA0-1]
DR Ensembl; ENST00000377585.7; ENSP00000366809.3; ENSG00000168065.16. [Q9NSA0-2]
DR GeneID; 55867; -.
DR KEGG; hsa:55867; -.
DR MANE-Select; ENST00000301891.9; ENSP00000301891.4; NM_018484.4; NP_060954.1.
DR UCSC; uc001oai.4; human. [Q9NSA0-1]
DR CTD; 55867; -.
DR DisGeNET; 55867; -.
DR GeneCards; SLC22A11; -.
DR HGNC; HGNC:18120; SLC22A11.
DR HPA; ENSG00000168065; Group enriched (epididymis, kidney, placenta).
DR MIM; 607097; gene.
DR neXtProt; NX_Q9NSA0; -.
DR OpenTargets; ENSG00000168065; -.
DR PharmGKB; PA38295; -.
DR VEuPathDB; HostDB:ENSG00000168065; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000163267; -.
DR InParanoid; Q9NSA0; -.
DR OMA; LIIMGKP; -.
DR OrthoDB; 464838at2759; -.
DR PhylomeDB; Q9NSA0; -.
DR TreeFam; TF315847; -.
DR PathwayCommons; Q9NSA0; -.
DR Reactome; R-HSA-561048; Organic anion transport.
DR SignaLink; Q9NSA0; -.
DR BioGRID-ORCS; 55867; 17 hits in 1075 CRISPR screens.
DR ChiTaRS; SLC22A11; human.
DR GeneWiki; SLC22A11; -.
DR GenomeRNAi; 55867; -.
DR Pharos; Q9NSA0; Tclin.
DR PRO; PR:Q9NSA0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9NSA0; protein.
DR Bgee; ENSG00000168065; Expressed in adult mammalian kidney and 78 other tissues.
DR ExpressionAtlas; Q9NSA0; baseline and differential.
DR Genevisible; Q9NSA0; HS.
DR GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005452; F:inorganic anion exchanger activity; IDA:UniProtKB.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015711; P:organic anion transport; IDA:UniProtKB.
DR GO; GO:0046415; P:urate metabolic process; IMP:BHF-UCL.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..550
FT /note="Solute carrier family 22 member 11"
FT /id="PRO_0000234435"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..174
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 368..378
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..402
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..430
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 452..463
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 485..490
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 512..550
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 531..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 353..461
FT /note="NFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTI
FT QAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVR
FT -> K (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_018319"
FT VARIANT 155
FT /note="V -> G (in dbSNP:rs12785832)"
FT /id="VAR_053962"
FT MUTAGEN 39
FT /note="N->Q: No visible effect on N-glycosylation. Loss of
FT N-glycosylation and of cell surface location; when
FT associated with Q-56; Q-63 and Q-99."
FT /evidence="ECO:0000269|PubMed:15576633"
FT MUTAGEN 47
FT /note="H->A: Reduced cell surface expression and estrone
FT sulfate transport. Reduced cell surface expression and
FT estrone sulfate transport; when associated with A-52; A-83;
FT A-305 and A-469."
FT /evidence="ECO:0000269|PubMed:15291761"
FT MUTAGEN 52
FT /note="H->A: Slightly reduced estrone sulfate transport.
FT Reduced cell surface expression and estrone sulfate
FT transport; when associated with A-47; A-83; A-305 and A-
FT 469."
FT /evidence="ECO:0000269|PubMed:15291761"
FT MUTAGEN 56
FT /note="N->Q: No visible effect on N-glycosylation. Loss of
FT N-glycosylation and of cell surface expression; when
FT associated with Q-39; Q-63 and Q-99."
FT /evidence="ECO:0000269|PubMed:15576633"
FT MUTAGEN 63
FT /note="N->Q: No visible effect on N-glycosylation. Loss of
FT N-glycosylation and of cell surface expression; when
FT associated with Q-39; Q-56 and Q-99."
FT /evidence="ECO:0000269|PubMed:15576633"
FT MUTAGEN 83
FT /note="H->A: Reduced cell surface expression and estrone
FT sulfate transport; when associated with A-47; A-52; A-305
FT and A-469."
FT /evidence="ECO:0000269|PubMed:15291761"
FT MUTAGEN 99
FT /note="N->Q: No visible effect on N-glycosylation. Loss of
FT N-glycosylation and of cell surface expression; when
FT associated with Q-39; Q-56 and Q-63."
FT /evidence="ECO:0000269|PubMed:15576633"
FT MUTAGEN 241
FT /note="G->L,S,V: Strongly reduced cell surface expression
FT and estrone sulfate transport."
FT /evidence="ECO:0000269|PubMed:15102942"
FT MUTAGEN 305
FT /note="H->A: Reduced cell surface expression and estrone
FT sulfate transport; when associated with A-47; A-52; A-83
FT and A-469."
FT /evidence="ECO:0000269|PubMed:15291761"
FT MUTAGEN 400
FT /note="G->L,S,V: Strongly reduced cell surface expression
FT and estrone sulfate transport."
FT /evidence="ECO:0000269|PubMed:15102942"
FT MUTAGEN 469
FT /note="H->A: Slightly reduced estrone sulfate transport.
FT Reduced cell surface expression and estrone sulfate
FT transport; when associated with A-47; A-52; A-83 and A-
FT 305."
FT /evidence="ECO:0000269|PubMed:15291761"
FT CONFLICT 180
FT /note="L -> S (in Ref. 3; BAD96589)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="L -> R (in Ref. 2; BAC85252)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 59972 MW; 233BE6C4A520E58A CRC64;
MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW THMLDNGSAV
STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA TATSWSEADT EPCVDGWVYD
RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM SGILVGSFIW GLLSYRFGRK PMLSWCCLQL
AVAGTSTIFA PTFVIYCGLR FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA
GQAALGGLAF ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA
RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML VVNFSLLISY
YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG RRTIQAGSQA MAGLAILANM
LVPQDLQTLR VVFAVLGKGC FGISLTCLTI YKAELFPTPV RMTADGILHT VGRLGAMMGP
LILMSRQALP LLPPLLYGVI SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ
EAVTVESTSL
