S22A7_HUMAN
ID S22A7_HUMAN Reviewed; 548 AA.
AC Q9Y694; B2CZX6; Q5T046; Q5T048; Q5T050; Q9H2W5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Solute carrier family 22 member 7;
DE AltName: Full=Novel liver transporter;
DE AltName: Full=Organic anion transporter 2;
DE Short=hOAT2;
GN Name=SLC22A7; Synonyms=NLT, OAT2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RA Kim R.B., Leake B.L., Cvetkovic M.;
RT "Molecular cloning of a human liver-specific transporter, NLT.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC TISSUE=Kidney;
RA Reid G., Bahn A., Ebbinghaus C., Wolff N.A., Burckhardt G.;
RT "Identification of a human organic anion transporter 2 homolog.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Kobayashi Y., Ohshiro N., Sekine T., Endoh H., Yamamoto T.;
RT "Cloning, characterization and localization of human organic anion
RT transporter 2.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LYS-303; TRP-327 AND
RP VAL-507.
RG NIEHS SNPs program;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11327718; DOI=10.1006/bbrc.2001.4774;
RA Sun W., Wu R.R., van Poelje P.D., Erion M.D.;
RT "Isolation of a family of organic anion transporters from human liver and
RT kidney.";
RL Biochem. Biophys. Res. Commun. 283:417-422(2001).
RN [10]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12023506; DOI=10.1124/jpet.301.3.797;
RA Enomoto A., Takeda M., Shimoda M., Narikawa S., Kobayashi Y., Kobayashi Y.,
RA Yamamoto T., Sekine T., Cha S.H., Niwa T., Endou H.;
RT "Interaction of human organic anion transporters 2 and 4 with organic anion
RT transport inhibitors.";
RL J. Pharmacol. Exp. Ther. 301:797-802(2002).
RN [11]
RP FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, AND
RP SUBCELLULAR LOCATION.
RX PubMed=11907186; DOI=10.1124/jpet.301.1.293;
RA Kimura H., Takeda M., Narikawa S., Enomoto A., Ichida K., Endou H.;
RT "Human organic anion transporters and human organic cation transporters
RT mediate renal transport of prostaglandins.";
RL J. Pharmacol. Exp. Ther. 301:293-298(2002).
RN [12]
RP FUNCTION, AND BIOPHYSICOCHEMICAL PROPERTIES.
RX PubMed=11855680; DOI=10.1254/jjp.88.69;
RA Babu E., Takeda M., Narikawa S., Kobayashi Y., Yamamoto T., Cha S.H.,
RA Sekine T., Sakthisekaran D., Endou H.;
RT "Human organic anion transporters mediate the transport of tetracycline.";
RL Jpn. J. Pharmacol. 88:69-76(2002).
RN [13]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15901346; DOI=10.1211/0022357055966;
RA Kobayashi Y., Ohshiro N., Sakai R., Ohbayashi M., Kohyama N., Yamamoto T.;
RT "Transport mechanism and substrate specificity of human organic anion
RT transporter 2 (hOat2 [SLC22A7]).";
RL J. Pharm. Pharmacol. 57:573-578(2005).
RN [14]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
CC -!- FUNCTION: Mediates sodium-independent multispecific organic anion
CC transport. Transport of prostaglandin E2, prostaglandin F2,
CC tetracycline, bumetanide, estrone sulfate, glutarate,
CC dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil,
CC paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-
CC ketoglutarate. {ECO:0000269|PubMed:11327718,
CC ECO:0000269|PubMed:11855680, ECO:0000269|PubMed:11907186,
CC ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:15901346}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=713 nM for prostaglandin E2 {ECO:0000269|PubMed:11855680,
CC ECO:0000269|PubMed:11907186};
CC KM=440 uM for tetracycline {ECO:0000269|PubMed:11855680,
CC ECO:0000269|PubMed:11907186};
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12023506}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:11907186,
CC ECO:0000269|PubMed:12023506}. Note=Apical side of the renal tubule.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9Y694-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y694-2; Sequence=VSP_030992;
CC Name=3;
CC IsoId=Q9Y694-3; Sequence=VSP_030992, VSP_030994;
CC Name=4;
CC IsoId=Q9Y694-4; Sequence=VSP_030991, VSP_030993;
CC -!- TISSUE SPECIFICITY: Expressed in liver and kidney.
CC {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:11907186,
CC ECO:0000269|PubMed:15901346}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/slc22a7/";
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DR EMBL; AF097518; AAD37091.1; -; mRNA.
DR EMBL; AF210455; AAG43523.1; -; mRNA.
DR EMBL; AY050498; AAL12496.1; -; mRNA.
DR EMBL; AK290796; BAF83485.1; -; mRNA.
DR EMBL; AK290806; BAF83495.1; -; mRNA.
DR EMBL; EU562669; ACB21045.1; -; Genomic_DNA.
DR EMBL; AL583834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX04172.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX04175.1; -; Genomic_DNA.
DR EMBL; BC033805; AAH33805.1; -; mRNA.
DR CCDS; CCDS4892.1; -. [Q9Y694-2]
DR CCDS; CCDS4893.2; -. [Q9Y694-1]
DR RefSeq; NP_006663.2; NM_006672.3. [Q9Y694-2]
DR RefSeq; NP_696961.2; NM_153320.2. [Q9Y694-1]
DR AlphaFoldDB; Q9Y694; -.
DR SMR; Q9Y694; -.
DR IntAct; Q9Y694; 2.
DR STRING; 9606.ENSP00000361666; -.
DR BindingDB; Q9Y694; -.
DR ChEMBL; CHEMBL1955711; -.
DR DrugBank; DB00437; Allopurinol.
DR DrugBank; DB00345; Aminohippuric acid.
DR DrugBank; DB00887; Bumetanide.
DR DrugBank; DB00456; Cefalotin.
DR DrugBank; DB01326; Cefamandole.
DR DrugBank; DB01329; Cefoperazone.
DR DrugBank; DB00493; Cefotaxime.
DR DrugBank; DB02659; Cholic Acid.
DR DrugBank; DB00501; Cimetidine.
DR DrugBank; DB01211; Clarithromycin.
DR DrugBank; DB02527; Cyclic adenosine monophosphate.
DR DrugBank; DB01160; Dinoprost tromethamine.
DR DrugBank; DB00917; Dinoprostone.
DR DrugBank; DB01248; Docetaxel.
DR DrugBank; DB00584; Enalapril.
DR DrugBank; DB00544; Fluorouracil.
DR DrugBank; DB01004; Ganciclovir.
DR DrugBank; DB03553; Glutaric Acid.
DR DrugBank; DB01016; Glyburide.
DR DrugBank; DB00328; Indomethacin.
DR DrugBank; DB01009; Ketoprofen.
DR DrugBank; DB00563; Methotrexate.
DR DrugBank; DB01017; Minocycline.
DR DrugBank; DB01303; Oxtriphylline.
DR DrugBank; DB00595; Oxytetracycline.
DR DrugBank; DB00175; Pravastatin.
DR DrugBank; DB01032; Probenecid.
DR DrugBank; DB01045; Rifampicin.
DR DrugBank; DB00936; Salicylic acid.
DR DrugBank; DB09327; Tegafur-uracil.
DR DrugBank; DB00624; Testosterone.
DR DrugBank; DB13943; Testosterone cypionate.
DR DrugBank; DB13944; Testosterone enanthate.
DR DrugBank; DB13946; Testosterone undecanoate.
DR DrugBank; DB00759; Tetracycline.
DR DrugBank; DB00277; Theophylline.
DR DrugBank; DB00313; Valproic acid.
DR DrugBank; DB00943; Zalcitabine.
DR DrugBank; DB00495; Zidovudine.
DR TCDB; 2.A.1.19.25; the major facilitator superfamily (mfs).
DR GlyGen; Q9Y694; 1 site.
DR iPTMnet; Q9Y694; -.
DR PhosphoSitePlus; Q9Y694; -.
DR BioMuta; SLC22A7; -.
DR DMDM; 74753520; -.
DR MassIVE; Q9Y694; -.
DR PaxDb; Q9Y694; -.
DR PeptideAtlas; Q9Y694; -.
DR PRIDE; Q9Y694; -.
DR ProteomicsDB; 86628; -. [Q9Y694-1]
DR ProteomicsDB; 86629; -. [Q9Y694-2]
DR ProteomicsDB; 86630; -. [Q9Y694-3]
DR ProteomicsDB; 86631; -. [Q9Y694-4]
DR Antibodypedia; 30365; 111 antibodies from 23 providers.
DR DNASU; 10864; -.
DR Ensembl; ENST00000372574.7; ENSP00000361655.3; ENSG00000137204.15. [Q9Y694-3]
DR Ensembl; ENST00000372585.10; ENSP00000361666.5; ENSG00000137204.15. [Q9Y694-1]
DR Ensembl; ENST00000372589.7; ENSP00000361670.3; ENSG00000137204.15. [Q9Y694-2]
DR GeneID; 10864; -.
DR KEGG; hsa:10864; -.
DR MANE-Select; ENST00000372585.10; ENSP00000361666.5; NM_153320.2; NP_696961.2.
DR UCSC; uc003ous.4; human. [Q9Y694-1]
DR CTD; 10864; -.
DR DisGeNET; 10864; -.
DR GeneCards; SLC22A7; -.
DR HGNC; HGNC:10971; SLC22A7.
DR HPA; ENSG00000137204; Tissue enriched (liver).
DR MIM; 604995; gene.
DR neXtProt; NX_Q9Y694; -.
DR OpenTargets; ENSG00000137204; -.
DR PharmGKB; PA35848; -.
DR VEuPathDB; HostDB:ENSG00000137204; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000154922; -.
DR HOGENOM; CLU_001265_33_3_1; -.
DR InParanoid; Q9Y694; -.
DR OMA; FPMETRA; -.
DR OrthoDB; 435631at2759; -.
DR PhylomeDB; Q9Y694; -.
DR TreeFam; TF315847; -.
DR PathwayCommons; Q9Y694; -.
DR Reactome; R-HSA-561048; Organic anion transport.
DR Reactome; R-HSA-9749641; Aspirin ADME.
DR SignaLink; Q9Y694; -.
DR BioGRID-ORCS; 10864; 9 hits in 1064 CRISPR screens.
DR ChiTaRS; SLC22A7; human.
DR GeneWiki; SLC22A7; -.
DR GenomeRNAi; 10864; -.
DR Pharos; Q9Y694; Tbio.
DR PRO; PR:Q9Y694; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9Y694; protein.
DR Bgee; ENSG00000137204; Expressed in right lobe of liver and 138 other tissues.
DR ExpressionAtlas; Q9Y694; baseline and differential.
DR Genevisible; Q9Y694; HS.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0015301; F:anion:anion antiporter activity; TAS:Reactome.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0015711; P:organic anion transport; TAS:ProtInc.
DR GO; GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00898; 2A0119; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..548
FT /note="Solute carrier family 22 member 7"
FT /id="PRO_0000317481"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 522..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT VAR_SEQ 1..307
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_030991"
FT VAR_SEQ 132..133
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_030992"
FT VAR_SEQ 308..317
FT /note="PVCEDSFSQE -> MLQPHLLPYQ (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_030993"
FT VAR_SEQ 531..548
FT /note="SAPTSLQEEEMPMKQVQN -> RCVHRTVSVYV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_030994"
FT VARIANT 303
FT /note="R -> K (in dbSNP:rs70953684)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_047875"
FT VARIANT 327
FT /note="R -> W (in dbSNP:rs36040909)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_047876"
FT VARIANT 507
FT /note="G -> V (in dbSNP:rs70953693)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_047877"
FT CONFLICT 304
FT /note="L -> P (in Ref. 2; AAG43523)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="T -> A (in Ref. 2; AAG43523)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 548 AA; 60026 MW; 5BA4C3FCC3C57533 CRC64;
MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA LPGAPANFSH
QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS RGELEDEPAT VPCSQGWEYD
HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV
STLVLGLASA ASVSYVMFAI TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW
TGGVMLLALV GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH
CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC VVVWFGVNFS
YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA GRRLTQAGTL LGTALAFGTR
LLVSSDMKSW STVLAVMGKA FSEAAFTTAY LFTSELYPTV LRQTGMGLTA LVGRLGGSLA
PLAALLDGVW LSLPKLTYGG IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE
MPMKQVQN
