ID   S17A5_SHEEP             Reviewed;         495 AA.
AC   Q9MZD1;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Sialin;
DE   AltName: Full=Membrane glycoprotein SP55;
DE   AltName: Full=Sodium/sialic acid cotransporter;
DE   AltName: Full=Solute carrier family 17 member 5;
GN   Name=SLC17A5;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Lung;
RX   PubMed=11751519;
RA   Fu C., Bardhan S., Cetateanu N.D., Wamil B.D., Wang Y., Yan H.-P., Shi E.,
RA   Carter C., Venkov C., Yakes F.M., Page D.L., Lloyd R.S., Mernaugh R.L.,
RA   Hellerqvist C.G.;
RT   "Identification of a novel membrane protein, HP59, with therapeutic
RT   potential as a target of tumor angiogenesis.";
RL   Clin. Cancer Res. 7:4182-4194(2001).
CC   -!- FUNCTION: Primary solute translocator for anionic substances;
CC       particularly it is a free sialic acid transporter in the lysosomes
CC       (Probable). Receptor for CM101, a polysaccharide produced by group B
CC       Streptococcus with antipathoangiogenic properties.
CC       {ECO:0000269|PubMed:11751519, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9NRA2};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NRA2}.
CC   -!- TISSUE SPECIFICITY: Significantly expressed in lung endothelial cells,
CC       and much less in liver. {ECO:0000269|PubMed:11751519}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC       cotransporter family. {ECO:0000305}.
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DR   EMBL; AF244578; AAF97770.1; -; mRNA.
DR   RefSeq; NP_001009742.1; NM_001009742.1.
DR   AlphaFoldDB; Q9MZD1; -.
DR   SMR; Q9MZD1; -.
DR   STRING; 9940.ENSOARP00000006649; -.
DR   GeneID; 443098; -.
DR   KEGG; oas:443098; -.
DR   CTD; 26503; -.
DR   eggNOG; KOG2532; Eukaryota.
DR   OrthoDB; 619250at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Phosphoprotein; Receptor; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..495
FT                   /note="Sialin"
FT                   /id="PRO_0000220949"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRA2"
SQ   SEQUENCE   495 AA;  54536 MW;  649D7C4A59B28272 CRC64;
     MKSPVSDLAP SDGEEGSDRT PLLQRAPRAE PAPVCCSARY NLAFLSFFGF FVLYSLRVNL
     SVALVDMVDS NTTAKDNRTS YECAEHSAPI KVLHNQTGKK YRWDAETQGW ILGSFFYGYI
     ITQIPGGYVA SRSGGKLLLG FGIFATAIFT LFTPLAADFG VGALVALRAL EGLGEGVTYP
     AMHAMWSSWA PPLERSKLLS ISYAGAQLGT VVSLPLSGVI CYYMNWTYVF YFFGIVGIIW
     FILWICLVSD TPETHKTITP YEKEYILSSL KNQLSSQKSV PWIPMLKSLP LWAIVVAHFS
     YNWTFYTLLT LLPTYMKEVL RFNIQENGFL SAVPYLGCWL CMILSGQAAD NLRARWNFST
     LWVRRVFSLI GMIGPAIFLV AAGFIGCDYS LAVAFLTIST TLGGFCSSGF SINHLDIAPS
     YAGILLGITN TFATIPGMIG PIIARSLTPE NTIGEWQTVF CIAAAINVFG AIFFTLFAKG
     EVQNWAISDH QGHRN