ID   RT4I1_DANRE             Reviewed;         387 AA.
AC   Q7T3C7;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Reticulon-4-interacting protein 1 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=rtn4ip1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=26593267; DOI=10.1016/j.ajhg.2015.09.012;
RA   Angebault C., Guichet P.O., Talmat-Amar Y., Charif M., Gerber S.,
RA   Fares-Taie L., Gueguen N., Halloy F., Moore D., Amati-Bonneau P., Manes G.,
RA   Hebrard M., Bocquet B., Quiles M., Piro-Megy C., Teigell M., Delettre C.,
RA   Rossel M., Meunier I., Preising M., Lorenz B., Carelli V., Chinnery P.F.,
RA   Yu-Wai-Man P., Kaplan J., Roubertie A., Barakat A., Bonneau D., Reynier P.,
RA   Rozet J.M., Bomont P., Hamel C.P., Lenaers G.;
RT   "Recessive mutations in RTN4IP1 cause isolated and syndromic optic
RT   neuropathies.";
RL   Am. J. Hum. Genet. 97:754-760(2015).
CC   -!- FUNCTION: Plays a role in the regulation of retinal ganglion cell (RGC)
CC       maturation, neurite outgrowth, and hence in the development of the
CC       inner retina and optic nerve (PubMed:26593267). Appears to be a potent
CC       inhibitor of regeneration following spinal cord injury (By similarity).
CC       {ECO:0000250|UniProtKB:Q924D0, ECO:0000269|PubMed:26593267}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q8WWV3}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH53171.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC053171; AAH53171.1; ALT_INIT; mRNA.
DR   RefSeq; NP_956646.1; NM_200352.1.
DR   AlphaFoldDB; Q7T3C7; -.
DR   SMR; Q7T3C7; -.
DR   STRING; 7955.ENSDARP00000040031; -.
DR   PaxDb; Q7T3C7; -.
DR   GeneID; 393323; -.
DR   KEGG; dre:393323; -.
DR   CTD; 84816; -.
DR   ZFIN; ZDB-GENE-040426-1314; rtn4ip1.
DR   eggNOG; KOG1198; Eukaryota.
DR   InParanoid; Q7T3C7; -.
DR   OrthoDB; 727365at2759; -.
DR   PhylomeDB; Q7T3C7; -.
DR   PRO; PR:Q7T3C7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0042462; P:eye photoreceptor cell development; IMP:ZFIN.
DR   GO; GO:0050773; P:regulation of dendrite development; ISS:UniProtKB.
DR   GO; GO:0010842; P:retina layer formation; IMP:UniProtKB.
DR   CDD; cd08248; RTN4I1; 1.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR037397; RTN4I1.
DR   Pfam; PF08240; ADH_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Neurogenesis;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..27
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..387
FT                   /note="Reticulon-4-interacting protein 1 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000042255"
SQ   SEQUENCE   387 AA;  42328 MW;  FAA0B7C5CDABAEE3 CRC64;
     MLMCRRWLVC SLRCHYRSFS FSAARRTVMP AWVIDKYGKN DVLRFTKNAA LPIIHYPNEV
     VVKVHAAGLN PIDISMRGGY GAATMAMKRD PLNISQSGGE FPLILGRDVS GEIMECGLDV
     KYFKPGDQVW AAIPPWKQGS LAEFVVVSGN EVSHKPKSLR HDEAASIPYV AATAWSAIVN
     TGGLNKDNSA KKRVLILGGS GGVGTFAIQM VKAWGAHVTV TCSQNAERLV RDLGADDVVD
     YTAGPVEKQL KNLEKFDLIL DSIGGETEKW ALDLLKPWSG AKFVTLITPF LQNTDRLGLA
     DGMMQSAVTV GCKVVKNLRK GVHYRWGFFA PSGSALDEVS EMVDAGKVRP VVEEVFSFAQ
     VPEAFQKVEQ GHARGKTVVS IMEDQKE